5 Result(s)
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Article
Open AccessThyroid and endostyle development in cyclostomes provides new insights into the evolutionary history of vertebrates
The endostyle is an epithelial exocrine gland found in non-vertebrate chordates (amphioxi and tunicates) and the larvae of modern lampreys. It is generally considered to be an evolutionary precursor of the thy...
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Open AccessShark genomes provide insights into elasmobranch evolution and the origin of vertebrates
Modern cartilaginous fishes are divided into elasmobranchs (sharks, rays and skates) and chimaeras, and the lack of established whole-genome sequences for the former has prevented our understanding of early ve...
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Article
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Mammalian non-homologous DNA end joining (NHEJ) is the primary pathway for the repair of DNA double-strand breaks (DSBs) throughout the cell cycle, including d...
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Open AccessDNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis
Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human c...
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Article
Open AccessConstruction and applications of exon-trap** gene-targeting vectors with a novel strategy for negative selection
Targeted gene modification by homologous recombination provides a powerful tool for studying gene function in cells and animals. In higher eukaryotes, non-homologous integration of targeting vectors occurs sev...
