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Open AccessReversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets
Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there ar...
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Open AccessHuman mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice
Mesenchymal stem cells (MSCs) are an attractive cell source for cell therapy. Based on our hypothesis that suppression of Wnt/β-catenin signal enhances hepatic differentiation of human MSCs, we developed human...
