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Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements

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  1. Article

    Open Access

    Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes

    Jill E. Moore, Michael J. Purcaro, Henry E. Pratt, Charles B. Epstein in Nature (2022)

  2. Article

    Open Access

    Detecting sample swaps in diverse NGS data types using linkage disequilibrium

    As the number of genomics datasets grows rapidly, sample mislabeling has become a high stakes issue. We present CrosscheckFingerprints (Crosscheck), a tool for quantifying sample-relatedness and detecting inco...

    Nauman Javed, Yossi Farjoun, Tim J. Fennell, Charles B. Epstein in Nature Communications (2020)

  3. Article

    Open Access

    Expanded encyclopaedias of DNA elements in the human and mouse genomes

    The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the ...

    Jill E. Moore, Michael J. Purcaro, Henry E. Pratt, Charles B. Epstein in Nature (2020)

  4. Article

    Open Access

    Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis

    Dual transcriptional profiling of host and bacteria during infection is challenging due to the low abundance of bacterial mRNA. We report Pathogen Hybrid Capture (PatH-Cap), a method to enrich for bacterial mR...

    Viktoria Betin, Cristina Penaranda, Nirmalya Bandyopadhyay, Rui Yang in Scientific Reports (2019)

  5. Article

    Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Paloma Cejas, Yotam Drier, Koen M. A. Dreijerink, Lodewijk A. A. Brosens in Nature Medicine (2019)

  6. Article

    Open Access

    Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA

    Rapid bacterial identification remains a critical challenge in infectious disease diagnostics. We developed a novel molecular approach to detect and identify a wide diversity of bacterial pathogens in a single...

    Roby P. Bhattacharyya, Mark Walker, Rich Boykin, Sophie S. Son in Scientific Reports (2019)

  7. Article

    Open Access

    Integrative analysis of 111 reference human epigenomes

    The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap...

    Anshul Kundaje, Wouter Meuleman, Jason Ernst, Misha Bilenky, Angela Yen in Nature (2015)

  8. Article

    Open Access

    Comparative analysis of metazoan chromatin organization

    A large collection of new modENCODE and ENCODE genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human are analysed; this reveals many conserved features of chromatin or...

    Joshua W. K. Ho, Youngsook L. Jung, Tao Liu, Burak H. Alver, Soohyun Lee in Nature (2014)

  9. Article

    Data exploration

    Enhancement of pattern discovery through graphical representation of data.

    Noam Shoresh, Bang Wong in Nature Methods (2012)

  10. Article

    Open Access

    Analytical Results for Individual and Group Selection of Any Intensity

    The idea of evolutionary game theory is to relate the payoff of a game to reproductive success (= fitness). An underlying assumption in most models is that fitness is a linear function of the payoff. For stoch...

    Arne Traulsen, Noam Shoresh, Martin A. Nowak in Bulletin of Mathematical Biology (2008)