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  1. No Access

    Article

    Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements

    Epigenomic maps identify gene regulatory elements by their chromatin state. However, prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate the interdependence of elements in...

    Sofia Battaglia, Kevin Dong, **gyi Wu, Zeyu Chen, Fadi J. Najm… in Nature Genetics (2022)

  2. No Access

    Article

    Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

    We introduce an approach to identify disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics. Our approach uses stratifie...

    Hilary K. Finucane, Yakir A. Reshef, Verneri Anttila, Kamil Slowikowski… in Nature Genetics (2018)

  3. No Access

    Article

    Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state

    Chromatin state is analyzed for the first time in single cells, revealing new cell subpopulations.

    Assaf Rotem, Oren Ram, Noam Shoresh, Ralph A Sperling, Alon Goren… in Nature Biotechnology (2015)

  4. No Access

    Article

    Exposing the fitness contribution of duplicated genes

    Duplicate genes from the whole-genome duplication (WGD) in yeast are often dispensable—removing one copy has little or no phenotypic consequence1,2. It is unknown, however, whether such dispensability reflects in...

    Alexander DeLuna, Kalin Vetsigian, Noam Shoresh, Matthew Hegreness… in Nature Genetics (2008)