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Article
Bacteria deplete deoxynucleotides to defend against bacteriophage infection
DNA viruses and retroviruses consume large quantities of deoxynucleotides (dNTPs) when replicating. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the viral lifecycle, and inhibits ...
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Chapter
“A Manly Amount of Wreckage”: South African Food Culture and Settler Belonging in Ivan Vladislavić’s Double Negative
This chapter reads South African author Ivan Vladislavić’s novel Double Negative as an interrogation of settler-colonial food culture. Eating habits and foodways reveal a tension between self-indigenising and sel...
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Article
Antiviral activity of bacterial TIR domains via immune signalling molecules
The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a ...
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Article
Open AccessAuthor Correction: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
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Article
Long-Term Aortic Valve Function in Patients With or Without Surgical Treatment for Discrete Subaortic Stenosis
The purpose of this study was to evaluate the long-term function of the aortic valve in patients with discrete subaortic stenosis (DSS), and its prognostic implications. 34 patients with the diagnosis of isola...
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Article
AUTS2 isoforms control neuronal differentiation
Mutations in AUTS2 are associated with autism, intellectual disability, and microcephaly. AUTS2 is expressed in the brain and interacts with polycomb proteins, yet it is still unclear how mutations in AUTS2 lead ...
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Article
Open AccessPogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators, including POGZ. The cellular and molecular mechanisms leading to ASD impaired social and cognitive behavior are unclear. Animal...