5 Result(s)
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Nirmish Singla
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessKidney double positive T cells have distinct characteristics in normal and diseased kidneys
Multiple types of T cells have been described and assigned pathophysiologic functions in the kidneys. However, the existence and functions of TCR+CD4+CD8+ (double positive; DP) T cells are understudied in norm...
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Article
Open AccessImmunomodulatory response to neoadjuvant nivolumab in non-metastatic clear cell renal cell carcinoma
Novel perioperative strategies are needed to reduce recurrence rates in patients undergoing nephrectomy for high-risk, non-metastatic clear cell renal cell carcinoma (ccRCC). We conducted a prospective, phase ...
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Article
Open AccessSingle cell and spatial transcriptomics analysis of kidney double negative T lymphocytes in normal and ischemic mouse kidneys
T cells are important in the pathogenesis of acute kidney injury (AKI), and TCR+CD4-CD8- (double negative-DN) are T cells that have regulatory properties. However, there is limited information on DN T cells compa...
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Article
Open AccessDeterminants of renal cell carcinoma invasion and metastatic competence
Metastasis is the principal cause of cancer related deaths. Tumor invasion is essential for metastatic spread. However, determinants of invasion are poorly understood. We addressed this knowledge gap by levera...
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Article
Open AccessCharacteristics and treatment outcomes of pan-urothelial cell carcinoma: a descriptive analysis of 45 patients
The incidence of pan-urothelial cell carcinoma (panUCC), which refers to the presence of both bilateral (UTUC) and bladder tumor (BT), is relatively low. However, the profile of a panUCC cohort of patients rem...
