3 Result(s)
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Nina M. S. Gustafsson
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Article
Open AccessPharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors ...
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Article
Open AccessThe γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of γ-tubulin facilitates the transport of proliferating cell nuclear an...
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Article
Open AccessTargeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-stra...
