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Article
Open AccessA pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ ol...
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Article
Open AccessTransient overexpression of alpha-Synuclein in OLN-93 oligodendroglial cells is not cytotoxic and not affected by HSP70
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Article
Preferences among four combination nicotine treatments
Acute nicotine replacement treatments (NRTs) are disliked or misused, leading to insufficient nicotine intake and poor outcome. Patches provide steady nicotine but are slow and passive. Combining systems may i...
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Article
The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress
Ubiquitinated tau-positive inclusion bodies in oligodendrocytes are consistent features in a variety of neurodegenerative disorders, and their formation points to an underlying incapacity of the protein qualit...
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Article
Comparison of three nicotine treatments: initial reactions and preferences with guided use
Misuse or dislike of nicotine replacement treatments (NRTs) undermines their effectiveness. Brief testing among NRTs could allow tailoring by preference to improve outcome.
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Article
Time course of smoking withdrawal symptoms as a function of nicotine replacement
Subjects (N=32) provided morning, afternoon, and evening data for week-1 withdrawal from smoking. Withdrawal symptoms were measured using Schneider's Smoker Complaint Scale. Twenty subjects received nicotine gum ...
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Article
Can cigarette size and nicotine content influence smoking and puffing rates?
The stimuli controlling the rate at which people smoke cigarettes have not been clearly defined. On the hypothesis that smoking is basically nicotine-seeking behavior. nicotine available to the subject was exp...