13 Result(s)
within
Nina G. **e
Biomedicine
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Article
Open AccessA pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ ol...
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Article
Open AccessDistribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations
The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D ...
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Article
Open AccessMetabolic consequences of perioperative oral carbohydrates in breast cancer patients — an explorative study
The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-...
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Article
Open AccessUpdated carrier rates for c.35delG (GJB2) associated with hearing loss in Russia and common c.35delG haplotypes in Siberia
Mutations in GJB2 gene are a major causes of deafness and their spectrum and prevalence are specific for various populations. The well-known mutation c.35delG is more frequent in populations of Caucasian origin. ...
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Article
Open AccessTransient overexpression of alpha-Synuclein in OLN-93 oligodendroglial cells is not cytotoxic and not affected by HSP70
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Article
Preferences among four combination nicotine treatments
Acute nicotine replacement treatments (NRTs) are disliked or misused, leading to insufficient nicotine intake and poor outcome. Patches provide steady nicotine but are slow and passive. Combining systems may i...
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Article
The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress
Ubiquitinated tau-positive inclusion bodies in oligodendrocytes are consistent features in a variety of neurodegenerative disorders, and their formation points to an underlying incapacity of the protein qualit...
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Article
Comparison of three nicotine treatments: initial reactions and preferences with guided use
Misuse or dislike of nicotine replacement treatments (NRTs) undermines their effectiveness. Brief testing among NRTs could allow tailoring by preference to improve outcome.
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Chapter
Hemolytic Activity of Triterpene Glycosides from the Dendrochirotida Order Holothurian
Triterpene glycosides from sea cucumbers are taxonomically specific,complicated and variable in their chemical structures and biological activities1. As well known cytotoxic, antifungal, and hemolytic effects of ...
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Chapter
Nicotine psychopharmacology in man
The present within-subjects, crossover study was designed to assess the short-term effects of several nicotine replacement strategies. After completing a 2 day smoking baseline, 18 (7 M, 11 F) smokers(≥ 20 cpd...
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Chapter and Conference Paper
Natural foci of arboviruses in far northern latitudes of Eurasia
From 1985–1988 we did virologie and serologic studies of hematophagous arthropods, small mammals, cattle and humans in northeastern Europe and Asia, i.e., in the arctic desert, in the moss-lichen and shrub tun...
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Article
Time course of smoking withdrawal symptoms as a function of nicotine replacement
Subjects (N=32) provided morning, afternoon, and evening data for week-1 withdrawal from smoking. Withdrawal symptoms were measured using Schneider's Smoker Complaint Scale. Twenty subjects received nicotine gum ...
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Article
Can cigarette size and nicotine content influence smoking and puffing rates?
The stimuli controlling the rate at which people smoke cigarettes have not been clearly defined. On the hypothesis that smoking is basically nicotine-seeking behavior. nicotine available to the subject was exp...
