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Article
Open AccessBackbone chemical shift and secondary structure assignments for mouse siderocalin
The lipocalin protein family is a structurally conserved group of proteins with a variety of biological functions defined by their ability to bind small molecule ligands and interact wit...
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Article
Open AccessA pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ ol...
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Article
Biophysics education section and computational training discussion at VII Congress of Russian Biophysicists
We present commentaries on the section “Biophysical education” of the VII Congress of Russian Biophysicists. Presentations are briefly introduced along with the current problems of biophysical education and th...
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Article
Bioinformatics tools for the sequence complexity estimates
We review current methods and bioinformatics tools for the text complexity estimates (information and entropy measures). The search DNA regions with extreme statistical characteristics such as low complexity r...
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Article
Coconut Flour (Cocos nucifera L.) as a Partial Replacement in Wheat Flour (Triticum aestivum)-Based Tortillas and Its Effect on Dough Rheology and Tortilla Quality
Wheat-flour (WF) tortillas are among the popular flatbreads used in northern Mexico to prepare ‘burritos’, which are widely accepted in the USA and other countries but have low nutritional quality. Therefore, ...
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Article
Wheat-Free and Nutritious Bread and ‘Coricos’ Made with Mesoamerican Ancestral Corn, Amaranth, Sweet Potato and Chia
People with wheat-related disorders require wheat-free and good quality baked goods. We prepared wheat-free bread and cookies (coricos) with flour blends of corn, amaranth, orange sweet potato and chia. Sweet ...
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Article
Open AccessDifferential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells
The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate. Pancreatic cancer subtypes have be...
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Article
Open AccessEarliest giant panda false thumb suggests conflicting demands for locomotion and feeding
Of the many peculiarities that enable the giant panda (Ailuropoda melanoleuca), a member of the order Carnivora, to adapt to life as a dedicated bamboo feeder, its extra “thumb” is arguably the most celebrated ye...
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Article
Open AccessComputational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals
Despite recent success in hepatitis C virus (HCV) treatment using antivirals, an HCV vaccine is still needed to prevent reinfections in treated patients, to avert the emergence of drug-resistant strains, and t...
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Article
Open AccessDesigning highly multiplex PCR primer sets with Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE)
One major challenge in the design of highly multiplexed PCR primer sets is the large number of potential primer dimer species that grows quadratically with the number of primers to be designed. Simultaneously,...
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Article
Deeper than the surface: Exploring symbolic cultural cues behind skin color among three groups of women of Chinese heritage
We integrated cosmetic and appearance-related scenario elicitation and in-depth interviews to explore aesthetic attitudes toward skin color in bicultural contexts among three groups of emerging Chinese adults....
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Chapter and Conference Paper
Unconventional Trajectories of Meteoroids in the Earth’s Atmosphere
We study the interaction of meteoroids with the Earth’s atmosphere. Based on the physical theory of meteoroids, we develop a model that describes the trajectories of celestial bodies in the Earth’s atmosphere....
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Article
Magnesium transport in the aglomerular kidney of the Gulf toadfish (Opsanus beta)
Despite having an aglomerular kidney, Gulf toadfish can survive in water ranging from nearly fresh up to 70 parts per thousand salinity. In hyperosmotic environments, the major renal function is to balance the...
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Article
Open AccessHigh-throughput phenoty** methods for quantifying hair fiber morphology
Quantifying the continuous variation in human scalp hair morphology is of interest to anthropologists, geneticists, dermatologists and forensic scientists, but existing methods for studying hair form are time-...
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Chapter and Conference Paper
Aspects of Meteoroids Flight in the Earth’s Atmosphere
We study the motion of meteoroids in the Earth’s atmosphere. It is shown that space bodies do not always fall on the Earth or explode and shatter into small fragments in the atmosphere. Instead, for certain ae...
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Chapter and Conference Paper
The Study of the Physical Processes that Cause the Destruction and Fragmentation of Meteoroids in the Atmosphere
We study the interaction of celestial bodies with the atmosphere of the Earth using the expanded physical theory of meteors. We describe the motion and destruction of three of some of the biggest meteoroids th...
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Article
Open AccessDietary and plasma blood α-linolenic acid as modulators of fat oxidation and predictors of aerobic performance
Among n-3 polyunsaturated fatty acids (PUFAs), the most important is α-linolenic acid (ALA). The biological activity of ALA is not equivalent to that of the long-chain n-3 PUFAs, and it has pleiotropic effects...
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Article
Multimodal map** of the tumor and peripheral blood immune landscape in human pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor microenvironment that renders it largely refractory to immunotherapy. We implemented a multimodal analysis approach to elu...
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Article
Open AccessDiB-splits: nature-guided design of a novel fluorescent labeling split system
Fluorogen-activating proteins (FAPs) are innovative fluorescent probes combining advantages of genetically-encoded proteins such as green fluorescent protein and externally added fluorogens that allow for high...
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Article
Open AccessDistribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations
The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D ...
