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Article
Cost effectiveness of breast cancer screening and prevention: a systematic review with a focus on risk-adapted strategies
Benefit and cost effectiveness of breast cancer screening are still matters of controversy. Risk-adapted strategies are proposed to improve its benefit-harm and cost–benefit relations. Our objective was to per...
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Article
Open AccessEffectiveness, benefit harm and cost effectiveness of colorectal cancer screening in Austria
Clear evidence on the benefit-harm balance and cost effectiveness of population-based screening for colorectal cancer (CRC) is missing. We aim to systematically evaluate the long-term effectiveness, harms and ...
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Article
Open AccessBenefits and harms of prostate cancer screening – predictions of the ONCOTYROL prostate cancer outcome and policy model
A recent recalibration of the ONCOTYROL Prostate Cancer Outcome and Policy (PCOP) Model, assuming that latent prostate cancer (PCa) detectable at autopsy might be detectable by screening as well, resulted in c...
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Article
Open AccessTherapy of uncomplicated falciparum malaria in Europe: MALTHER – a prospective observational multicentre study
Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of...
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Article
Open AccessHCV-related burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, end-stage cirrhosis, and liver cancer, but little is known about the burden of disease caused by the virus. We summarised burden of disease ...
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Article
Open AccessThe low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis?
A comparison was made between local malaria transmission and malaria imported by travellers to identify the utility of national and regional annual parasite index (API) in predicting malaria risk and its value...
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Article
Open AccessMolecular surveillance of the antifolate-resistant mutation I164L in imported african isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop
Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this mutation in Afri...
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Article
Open AccessMolecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe
Results from numerous studies point convincingly to correlations between mutations at selected genes and phenotypic resistance to antimalarials in Plasmodium falciparum isolates. In order to move molecular assays...
