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  1. Article

    Open Access

    Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties

    The dominant hypothesis about the pathogenesis of Alzheimer’s disease (AD) is the “amyloid cascade” concept and modulating the expression of proteins involved in the metabolism of amyloid-beta (Aβ) is propose...

    Maria A. Tikhonova, Tamara G. Amstislavskaya, Victor M. Belichenko… in BMC Neuroscience (2018)

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    Article

    New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes

    Currently, deficit of amyloid β-peptide (Aβ) clearance from the brain is considered as one of the possible causes of amyloid accumulation and neuronal death in the sporadic form of Alzheimer’s disease (AD). Aβ...

    Natalia N. Nalivaeva, Nikolai D. Belyaev, Anthony J. Turner in Neurochemical Research (2016)

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    Article

    Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats

    Alzheimer's disease (AD) is accompanied by memory loss due to neuronal cell death caused by toxic amyloid β-peptide (Aβ) aggregates. In the healthy brain, a group of amyloid-degrading enzymes including neprily...

    Natalia N. Nalivaeva, Nikolai D. Belyaev… in Journal of Molecular Neuroscience (2012)

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    Article

    Centromere-specific acetylation of histone H4 in barley detected through three-dimensional microscopy

    Histone acetylation affects chromatin conformation and transcriptional activity. However, the structural role of histone acetylation at specific chromosomal regions, such as the centromere, is poorly understoo...

    Toshiyuki Wako, Andreas Houben, Rieko Furushima-Shimogawara… in Plant Molecular Biology (2003)

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    Article

    Cell cycle-dependent and lysine residue-specific dynamic changes of histone H4 acetylation in barley

    Histone acetylation affects chromatin conformation and regulates various cellular functions, such as transcription and cell cycle progression. Although mitosis dependent transcriptional silencing and large-sca...

    Toshiyuki Wako, Michiyo Fukuda, Rieko Furushima-Shimogawara… in Plant Molecular Biology (2002)

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    Article

    Histone H4 acetylation in plant heterochromatin is altered during the cell cycle

    Using polyclonal antibodies directed against acetylated isoforms of histone H4 (H4 acetylated at lysine positions 5, 8, 12, 16 and H4 tetraacetylated), indirect immunofluorescence revealed hyperacetylation for...

    Nikolai D. Belyaev, Andreas Houben, Pawel Baranczewski, Ingo Schubert in Chromosoma (1997)

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    Article

    Differences of histone H4 acetylation and replication timing between A and B chromosomes of Brachycome dichromosomatica

    Differences are demonstrated between A (transcriptionally active) and B (transcriptionally inactive) chromosomes that are characterized by a different level of histone H4 acetylation and a different timing of ...

    Andreas Houben, Nikolai D. Belyaev, Carolyn R. Leach… in Chromosome Research (1997)

  8. No Access

    Article

    Differential underacetylation of histones H2A, H3 and H4 on the inactive X chromosome in human female cells

    It has previously been shown that the acetylated forms of histone H4 are depleted or absent in both constitutive, centric heterochromatin and in the facultative heterochromatin of the inactive X chromosome (**...

    Nikolai D. Belyaev, Ann M. Keohane, Bryan M. Turner in Human Genetics (1996)

  9. No Access

    Article

    Differential immunostaining of plant chromosomes by antibodies recognizing acetylated histone H4 variants

    Metaphase chromosomes ofVicia faba were exposed to antibodies recognizing defined acetylated isoforms of histone H4. After indirect immunostaining with antibodies directed against H4 acetylated on lysines 5, 8 an...

    Andreas Houben, Nikolai D. Belyaev, Bryan M. Turner, Ingo Schubert in Chromosome Research (1996)