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    Article

    Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging

    Molecular classification has transformed the management of brain tumors by enabling more accurate prognostication and personalized treatment. However, timely molecular diagnostic testing for patients with brai...

    Todd Hollon, Cheng Jiang, Asadur Chowdury, Mustafa Nasir-Moin in Nature Medicine (2023)

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    Open Access

    Novel rapid intraoperative qualitative tumor detection by a residual convolutional neural network using label-free stimulated Raman scattering microscopy

    Determining the presence of tumor in biopsies and the decision-making during resections is often dependent on intraoperative rapid frozen-section histopathology. Recently, stimulated Raman scattering microscop...

    David Reinecke, Niklas von Spreckelsen in Acta Neuropathologica Communications (2022)

  3. Article

    Open Access

    KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

    Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical...

    Niklas von Spreckelsen, Natalie Waldt in Acta Neuropathologica Communications (2020)