9 Result(s)
within
Niklas von Spreckelsen
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Article
Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging
Molecular classification has transformed the management of brain tumors by enabling more accurate prognostication and personalized treatment. However, timely molecular diagnostic testing for patients with brai...
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Article
Open AccessNovel rapid intraoperative qualitative tumor detection by a residual convolutional neural network using label-free stimulated Raman scattering microscopy
Determining the presence of tumor in biopsies and the decision-making during resections is often dependent on intraoperative rapid frozen-section histopathology. Recently, stimulated Raman scattering microscop...
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Article
Open AccessVentriculostomy-related intracranial hemorrhage following surgical and endovascular treatment of ruptured aneurysms
Endovascular therapy of ruptured aneurysms is regularly accompanied by periprocedural heparinization and requires the use of periprocedural antiplatelets in more complex cases. This raises concerns regarding i...
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Article
Open AccessCyberknife® hypofractionated stereotactic radiosurgery (CK-hSRS) as salvage treatment for brain metastases
The introduction of hypofractionated stereotactic radiosurgery (hSRS) extended the treatment modalities beyond the well-established single-fraction stereotactic radiosurgery and fractionated radiotherapy. Here...
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Article
Open AccessKLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical...
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Article
Flow-regulated versus differential pressure valves for idiopathic normal pressure hydrocephalus: comparison of overdrainage rates and neurological outcome
To compare flow-regulated (FR) and differential pressure (DP) valves for treatment of patients with idiopathic normal hydrocephalus (iNPH) focusing on overdrainage and neurological outcome.
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Article
Impact of aneurysm shape on morbidity after clip** of unruptured intracranial aneurysms
Complex aneurysm shape is a predominant risk factor for aneurysm rupture but its impact on clinical outcome after clip** remains unclear. The objective of the present study was to compare complications and m...
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Article
Current treatment concepts for iatrogenic ventriculitis: a nationwide survey in Germany
Iatrogenic ventriculitis is a common complication of the external ventricular drainage. While the procedure and indications for external ventricular drains (EVD) are highly standardized, the treatment of ventr...
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Chapter
The Different Forms of Moyamoya Disease and Their Clinical Management
Ever since the first description of moyamoya in 1957, many advances in diagnosis and treatment have been made. While the treatment of the disease mainly remains surgical due to lack of medical treatment option...
