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Article
The role of asymmetric dimethylarginine in endothelial dysfunction and abnormal nitric oxide metabolism in systemic sclerosis: results from a pilot study
Systemic sclerosis (SSc) is characterized by generalized vasculopathy affecting mainly small vessels while macrovascular involvement is less investigated. The aim of this study was to examine associations betw...
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Article
Open AccessReal world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease
to assess the effects of cilostazol on pain-free walking distance in PAD patients with IC at 3 and 6 months in a real world, prospective, observational study. We included 1015 PAD patients presenting with IC (...
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Article
Open AccessMediterranean Diet and Obesity-related Disorders: What is the Evidence?
Obesity is a chronic disease, a major public health problem due to its association with non-communicable diseases and all-cause mortality. Indeed, people with obesity are at increased risk for a variety of obe...
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Article
Open AccessPersonalized management of dyslipidemias in patients with diabetes—it is time for a new approach (2022)
Dyslipidemia in patients with type 2 diabetes (DMT2) is one of the worst controlled worldwide, with only about 1/4 of patients being on the low-density lipoprotein cholesterol (LDL-C) target. There are many re...
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Article
Semaglutide, cilofexor, and firsocostat for nonalcoholic steatohepatitis: a dance that may need more than one dancer
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Article
Statins and diabetes mellitus progression: a fly in the ointment?
Statins might exert diabetogenic effects, potentially increasing insulin resistance and worsening glucose control. However, patients with diabetes mellitus are at high or very high cardiovascular risk and, thu...
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Chapter
Antidiabetic Drugs in COVID-19
Diabetes mellitus (DM) has been linked to COVID-19 incidence, severity, and worse outcomes. Antidiabetic drugs have been suggested to affect COVID-19 outcomes via several mechanisms, including their glucose-lo...
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Article
Peripheral microcirculatory abnormalities are associated with cardiovascular risk in systemic sclerosis: a nailfold video capillaroscopy study
Microvascular dysfunction is the key element in the pathogenesis of systemic sclerosis (SSc), whereas the contribution of large and medium size vessel abnormalities is yet to be established. The aim of the pre...
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Article
Open AccessInfluence of dietary intervention on microvascular endothelial function in coronary patients and atherothrombotic risk of recurrence
Endothelial dysfunction is a key player in both the onset and development of atherosclerosis. No study has examined whether healthy dietary patterns can improve microvascular endothelial function in patients w...
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Article
Olive Oil Intake and Cardiovascular Disease Prevention: “Seek and You Shall Find”
The present narrative review focuses on the up-to-date clinical data on the correlations between olive oil consumption and cardiovascular (CV) diseases (i.e., CHD, stroke, and peripheral artery disease).
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Article
Effects of Sacubitril/Valsartan in Patients with High Arrhythmic Risk and an ICD: A Longitudinal Study
Patients affected by heart failure with reduced ejection fraction (HFrEF) receive clinical and functional beneficial effects from treatment with sacubitril/valsartan. However previous studies have shown that p...
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Article
Open AccessLonger sleep duration may negatively affect renal function
Observational studies evaluating the link between sleep duration and kidney function reported controversial results. In the present study, Mendelian randomization analysis was applied to obtain unconfounded es...
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Article
NAFLD and Statins
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Article
Open AccessAchieving low-density lipoprotein cholesterol targets as assessed by different methods in patients with familial hypercholesterolemia: an analysis from the HELLAS-FH registry
Familial hypercholesterolemia (FH) is characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels and increased cardiovascular disease (CVD) risk. FH patients often have increased lipoprotein(...
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Article
Open AccessArterial stiffness correlates with progressive nailfold capillary microscopic changes in systemic sclerosis: results from a cross-sectional study
While microangiopathy is well-documented in systemic sclerosis (SSc), a potential link between SSc and macrovascular disease is highly debated and remains to be established. The aim of the present study is to ...
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Article
Metabolic syndrome: joint diagnostic criteria and links with comorbidities
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Chapter
Prehypertension, the Risk of Hypertension and Events
Prehypertension is a precursor of hypertension in a high proportion of individuals. Several factors may predispose to the development of prehypertension including uric acid, dietary salt intake, arterial stiff...
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Article
Lipids: a personal view of the past decade
The past decade has witnessed considerable progress in the field of lipids. New drugs have been “rapidly” developed and some of these drugs have already been evaluated in event-based large trials. This evidenc...
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Article
Open AccessAdiposity mediates the association between whole grain consumption, glucose homeostasis and insulin resistance: findings from the US NHANES
Growing evidence suggests an inverse association between whole grain (WG) consumption and insulin resistance (IR) or inflammation. However, it is still unclear whether adiposity plays a role in this relationship.
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Article
Leptin, cardiovascular diseases and type 2 diabetes mellitus
Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness, angiogenesis and atherogenesis...
