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  1. No Access

    Article

    Impact of the first wave of COVID-19 epidemy on the surgical management of sigmoid diverticular disease in France: National French retrospective study

    To analyze the surgical management of sigmoid diverticular disease (SDD) before, during, and after the first containment rules (CR) for the first wave of COVID-19.

    Camille Gil, Laura Beyer-Bergeot in International Journal of Colorectal Disease (2023)

  2. Article

    Open Access

    The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus

    Evidence from previous studies suggests a protective effect of metformin in patients with colorectal cancer (CRC). The aim of this study was to examine the associations between metformin use and overall surviv...

    Zeinab Tarhini, Kamelia Manceur, Julien Magne, Muriel Mathonnet in Scientific Reports (2022)

  3. No Access

    Article

    Gastric Pneumatosis with Portal Venous Gas can be Treated Non-operatively: A Retrospective Multi-institutional Study

    Gastric pneumatosis (GP) is a rare radiologic finding with an unpredictable prognosis. The aim of this study was to identify mortality risk factors from patients presenting with GP on computed tomography (CT),...

    Antoine Epin, Guillaume Passot, Niki Christou, Olivier Monneuse in World Journal of Surgery (2022)

  4. Article

    Open Access

    Contemporary snapshot of tumor regression grade (TRG) distribution in locally advanced rectal cancer: a cross sectional multicentric experience

    Pre-operative chemoradiotherapy (CRT) followed by surgical resection is still the standard treatment for locally advanced low rectal cancer. Nowadays new strategies are emerging to treat patients with a comple...

    Paola Germani, Francesca Di Candido, Daniel Léonard, Dajana Cuicchi in Updates in Surgery (2021)

  5. Article

    Open Access

    ONCOGRAM: study protocol for the evaluation of therapeutic response and survival of metastatic colorectal cancer patients treated according to the guidelines of a chemosensitivity assay, the Oncogramme®

    Colorectal cancer is a major public concern, being the second deadliest cancer in the world. Whereas survival is high for localized forms, metastatic colorectal cancer has showed poor prognosis, with a 5-year ...

    Muriel Mathonnet, Mathieu Vanderstraete, Christophe Bounaix Morand du Puch in Trials (2021)

  6. Article

    Open Access

    Prevalence of Metastatic Lateral Lymph Nodes in Asian Patients with Lateral Lymph Node Dissection for Rectal Cancer: A Meta-analysis

    Rectal cancers occupy the eighth position worldwide for new cases and deaths for both men and women. These cancers have a high tendency to form metastases in the mesorectum but also in the lateral lymph nodes....

    Niki Christou, Jeremy Meyer, Christophe Combescure in World Journal of Surgery (2021)

  7. Article

    Open Access

    Sacro-coxxygial hygiene, a key factor in the outcome of pilonidal sinus surgical treatment?

    Surgical wound infection contributes to prolonged recovery time after pilonidal sinus excision. As a standard procedure after surgery, we recommend our patients to perform water irrigations in the intergluteal...

    Arnaud Dupuis, Niki Christou, Dorota Teterycz, Alexandre Balaphas in BMC Surgery (2021)

  8. Article

    Open Access

    C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh

    The introduction of biological or absorbable synthetic meshes has provided an alternative to conventional repair for incisional hernia. The ability to predict the development of complications after hernia surg...

    Julien Janet, Sophiane Derbal, Sylvaine Durand Fontanier in Scientific Reports (2021)

  9. No Access

    Article

    Implantation of biologic mesh in ventral hernia repair—does it make sense?

    Biological acellular porcine dermis mesh, such as Permacol™, has been used since 2009 to treat abdominal incisional hernias in a septic context. This study investigated the risk factors for incisional hernia r...

    Abdelkader Taibi, Sophiane Derbal, Sylvaine Durand Fontanier in Surgical Endoscopy (2021)

  10. Article

    Open Access

    Neurotensin pathway in digestive cancers and clinical applications: an overview

    Initially, NEUROTENSIN (NTS) has been shown to play physiological and biological functions as a neuro-transmitter/modulator in the central nervous system and as an endocrine factor in the periphery, through it...

    Niki Christou, Sabrina Blondy, Valentin David, Mireille Verdier in Cell Death & Disease (2020)

  11. No Access

    Article

    Total mesorectal excision with and without lateral lymph node dissection: a systematic review of the literature

    Treatment of lateral lymph node metastasis in rectal cancer is still under debate. While these nodes are routinely resected by Japanese teams, neoadjuvant radiochemotherapy alone is performed in Western countr...

    Gregoire Longchamp, Jeremy Meyer in International Journal of Colorectal Disease (2020)

  12. Article

    Open Access

    Identification of risk factors for morbidity and mortality after Hartmann’s reversal surgery – a retrospective study from two French centers

    Hartmann’s reversal procedures are often fraught with complications or failure to recover. This being a fact, it is often difficult to select patients with the optimal indications for a reversal. The post-reco...

    Niki Christou, Thibaud Rivaille, Charlotte Maulat, Abdelkader Taibi in Scientific Reports (2020)

  13. No Access

    Article

    One-Year Postoperative Mortality in MEN1 Patients Operated on Gastric and Duodenopancreatic Neuroendocrine Tumors: An AFCE and GTE Cohort Study

    In MEN1 patients with gastric and duodenopancreatic neuroendocrine tumors (GPD-NET), surgery aims to control secretions or to prevent metastatic spread, but after GPD-NET resection, postoperative mortality may...

    Niki Christou, Muriel Mathonnet, Sébastien Gaujoux in World Journal of Surgery (2019)

  14. Article

    Open Access

    Neurotrophins and their involvement in digestive cancers

    Cancers of the digestive system, including esophageal, gastric, pancreatic, hepatic, and colorectal cancers, have a high incidence and mortality worldwide. Efficient therapies have improved patient care; howev...

    Sabrina Blondy, Niki Christou, Valentin David, Mireille Verdier in Cell Death & Disease (2019)

  15. No Access

    Article

    The extracellular domain of E cadherin linked to invasiveness in colorectal cancer: a new resistance and relapses monitoring serum-bio marker?

    Multiple studies have attempted to demonstrate the interest of the cell adhesion marker, E cadherin, as a diagnostic and prognosis marker in colorectal cancer (CRC). However, it was considered non specific.

    Niki Christou, Aurélie Perraud in Journal of Cancer Research and Clinical On… (2017)

  16. No Access

    Article

    Assessment of the Aldosteronona resolution score as a predictive resolution score of hypertension after adrenalectomy for aldosteronoma in French patients

    Aldosteronoma Resolution Score (ARS) is a predictive score for cure of hypertension after adrenalectomy for hyperaldosteronism and has been validated in American patients. The aim of the study was to validate ...

    Ludwig Pasquier, Medhi Kirouani, Florian Fanget in Langenbeck's Archives of Surgery (2017)

  17. No Access

    Article

    New ex-ovo colorectal-cancer models from different SdFFF-sorted tumor-initiating cells

    Despite effective treatments, relapse of colorectal cancer (CRC) is frequent, in part caused by the existence of tumor-initiating cells (TICs). Different subtypes of TICs, quiescent and activated, coexist in t...

    Carole Mélin, Aurélie Perraud, Niki Christou in Analytical and Bioanalytical Chemistry (2015)

  18. No Access

    Article

    Management of thyroid nodules incidentally discovered on MIBI scanning for primary hyperparathyroidism

    Parathyroid sestamibi scan is routinely performed before parathyroid surgery. A large number of thyroid cancers take up 99mTc-sestamibi (MIBI). Since 2001, thyroid nodules discovered on sestamibi, nodules >2 c...

    Tristan Greilsamer, Claire Blanchard, Niki Christou in Langenbeck's Archives of Surgery (2015)