5 Result(s)
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Article
Open AccessAuthor Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
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Article
Open AccessSARS-CoV-2 infection and replication in human gastric organoids
COVID-19 typically manifests as a respiratory illness, but several clinical reports have described gastrointestinal symptoms. This is particularly true in children in whom gastrointestinal symptoms are frequen...
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Open AccessSomatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genoty** in ...
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Article
Open AccessMulti-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors
A tissue engineered oesophagus could overcome limitations associated with oesophageal substitution. Combining decellularized scaffolds with patient-derived cells shows promise for regeneration of tissue defect...
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Article
Open AccessTransplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon
Enteric nervous system neuropathy causes a wide range of severe gut motility disorders. Cell replacement of lost neurons using enteric neural stem cells (ENSC) is a possible therapy for these life-limiting dis...
