Pediatric Neurogastroenterology
Gastrointestinal Motility Disorders and Disorders of Gut Brain Interaction in Children
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Navigating through 65 years of insights: lessons learned on functional abdominal pain in children
In 1958, Apley and Naish authored a groundbreaking paper in Archives of Disease in Childhood, elucidating the epidemiology and risk factors of recurrent abdominal pain in children—a subject that had confounded...
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Chronic Diarrhea in Children
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Celiac Disease in Children: A 2023 Update
Celiac disease (CeD) is a chronic immune-mediated enteropathy, which occurs in genetically predisposed individuals by the ingestion of gluten proteins present in wheat, barley and rye. The global pooled preval...
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Article
Open AccessMulti-disciplinary Insights from the First European Forum on Visceral Myopathy 2022 Meeting
Visceral myopathy is a rare, life-threatening disease linked to identified genetic mutations in 60% of cases. Mostly due to the dearth of knowledge regarding its pathogenesis, effective treatments are lacking....
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Myths and misconceptions about childhood constipation
Many widely held beliefs and assumptions concerning childhood constipation continue to interfere with rational management of childhood constipation. Although many still believe that constipation is not a commo...
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Open AccessAuthor Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
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Correction to: Pediatric Neurogastroenterology
Christophe Faure, Nikhil Thapar, Carlo Di Lorenzo (eds.), Pediatric Neurogastroenterology, https://doi.org/ 978-3-031-15228-3
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Introduction to Gut Motility and Sensitivity
The diverse functions of the GI tract are dependent on highly coordinated sensory and effector mechanisms, which monitor the GI lumen and wall, respond to specific cues and interact with a diversity of cell ty...
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Antroduodenal Manometry
Antroduodenal manometry provides a neuromuscular assessment of gastric antrum and proximal small bowel. Although it is a complex diagnostic tool requiring considerable experience and skills for its performance...
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Pediatric Intestinal Pseudo-Obstruction
Chronic intestinal pseudo-obstruction (CIPO) represents the most severe end of the spectrum of gut motility disorders comprising a group of rare, heterogeneous, and disabling disorders of the gastrointestinal ...
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Cellular-Based Therapies for Paediatric GI Motility Disorders
Therapeutic options for many gastrointestinal (GI) motility disorders, especially the most severe, remain inadequate and limited to palliative interventions. Advances in molecular biology and genetics have led...
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Article
Open AccessSARS-CoV-2 infection and replication in human gastric organoids
COVID-19 typically manifests as a respiratory illness, but several clinical reports have described gastrointestinal symptoms. This is particularly true in children in whom gastrointestinal symptoms are frequen...
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Open AccessCombined treatment with enteric neural stem cells and chondroitinase ABC reduces spinal cord lesion pathology
Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-...
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Paediatric functional abdominal pain disorders
Paediatric functional abdominal pain disorders, currently referred to as disorders of gut–brain interaction, comprise irritable bowel syndrome, functional dyspepsia, abdominal migraine and functional abdominal...
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Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure
Intestinal failure, following extensive anatomical or functional loss of small intestine, has debilitating long-term consequences for children1. The priority of patient care is to increase the length of functiona...
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Open AccessERNICA guidelines for the management of rectosigmoid Hirschsprung’s disease
Hirschsprung’s disease (HSCR) is a serious congenital bowel disorder with a prevalence of 1/5000. Currently, there is a lack of systematically developed guidelines to assist clinical decision-making regarding ...
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Article
Open AccessSomatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genoty** in ...
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Open AccessIsolation and characterisation of mouse intestinal mesoangioblasts
Children suffering from intestinal failure (IF) endure considerable morbidity and overall have poor survival rates, complicated by the shortage of organs available for transplantation. Therefore, new therapeut...
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Stem Cell Therapy for Enteric Neuropathies
Enteric neuropathies, such as Hirschsprung disease (HSCR), comprise a number of severe diseases of the enteric nervous system (ENS) of the gastrointestinal (GI) tract with, as yet, no cures. The replacement of...
