8 Result(s)
within
Nigel C Bennett
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessNaked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles
The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms...
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Article
Open AccessAdult stem cell activity in naked mole rats for long-term tissue maintenance
The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lif...
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Article
Open AccessNaked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body temperature (Tb) decreases via unknown mechanisms to conserve energy. In small mammals, non-shivering thermogenesis in brown...
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Article
Open AccessAmplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains
To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16 brains from 14 cetartiodactyl species, with immunohistochemical techniques, for evidence of non-shivering thermogenesi...
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Open AccessPublisher Correction: Lipidome determinants of maximal lifespan in mammals
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessLocally-curved geometry generates bending cracks in the African elephant skin
An intricate network of crevices adorns the skin surface of the African bush elephant, Loxodonta africana. These micrometre-wide channels enhance the effectiveness of thermal regulation (by water retention) as we...
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Article
Open AccessSociality does not drive the evolution of large brains in eusocial African mole-rats
The social brain hypothesis (SBH) posits that the demands imposed on individuals by living in cohesive social groups exert a selection pressure favouring the evolution of large brains and complex cognitive abi...
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Open AccessLipidome determinants of maximal lifespan in mammals
Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationshi...
