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    Article

    HER2 expression identifies dynamic functional states within circulating breast cancer cells

    Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast tumours.

    Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio in Nature (2016)

  2. Article

    Open Access

    Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

    Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs fro...

    Yu Zheng, David T. Miyamoto, Ben S. Wittner, James P. Sullivan in Nature Communications (2017)

  3. Article

    Open Access

    PAX8 lineage-driven T cell engaging antibody for the treatment of high-grade serous ovarian cancer

    High-grade serous ovarian cancers (HGSOC) represent the most common subtype of ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of recurrence following standard of care treatme...

    Emily Lee, Sarah Szvetecz, Ryan Polli, Angelo Grauel, Jayson Chen in Scientific Reports (2021)