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Article
Open AccessAn international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer
Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalities remain unclear. Here, we report the colorectal (CRC) cohort analysis from the SABR-PD...
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Article
Emergency radiation therapy in modern-day practice: Now or never, or never again ?
Radiation therapy plays a fundamental role in oncological emergencies such as superior vena cava syndrome (SVCS) and metastatic epidural spinal cord compression (MESCC). These are two examples of critical comp...
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Article
New photobiomodulation device for prevention and cure of radiotherapy-induced oral mucositis and dermatitis: results of the prospective Safe PBM study
The study aims to assess the feasibility, safety, and tolerability of CareMin650, a new photobiomodulation device, in patients treated by radiotherapy (RT) and to collect preliminary data on efficacy for preve...
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Article
Photobiomodulation by a new optical fiber device: analysis of the in vitro impact on proliferation/migration of keratinocytes and squamous cell carcinomas cells stressed by X-rays
Photobiomodulation-based (PBM-based) therapies show promising results in mucositis and dermatitis treatment by stimulating wound healing mechanisms such as cell proliferation and migration. The aim of the pres...
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Article
Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma
The clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor, partly due to the presence of resistant cancer stem cells (CSCs) which are responsible of recurrences. CSCs have low EGFR exp...
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Article
Open AccessMechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a sco** review
Oral mucositis (OM) is a severe complication cancer patients undergo when treated with chemoradiotherapy. Photobiomodulation (PBM) therapy also known as low-level laser therapy has been increasingly used for t...
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Article
Open AccessAssessment of non-inferiority with meta-analysis: example of hypofractionated radiation therapy in breast and prostate cancer
The aim of this study was to propose a methodology for the assessment of non-inferiority with meta-analysis. Assessment of hypofractionated RT in prostate and breast cancers is used as an illustrative example....
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Article
Open AccessRadiation-induced bystander and abscopal effects: important lessons from preclinical models
Radiotherapy is a pivotal component in the curative treatment of patients with localised cancer and isolated metastasis, as well as being used as a palliative strategy for patients with disseminated disease. T...
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Article
Open AccessSurvival after hypofractionation in glioblastoma: a systematic review and meta-analysis
Glioblastoma multiforme (GBM) has a poor prognosis despite a multi modal treatment that includes normofractionated radiotherapy. So, various hypofractionated alternatives to normofractionated RT have been test...
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Article
Open AccessCBCT evaluation of inter- and intra-fraction motions during prostate stereotactic body radiotherapy: a technical note
In most clinical trials, gold fiducial markers are implanted in the prostate to tune the table position before each radiation beam. Yet, it is unclear if a cone-beam computed tomography (CBCT) should be perfor...
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Article
Safety assessment of anticancer drugs in association with radiotherapy in metastatic malignant melanoma: a real-life report
To assess the safety of the association of radiotherapy (RT) and systemic treatments for patients with metastatic malignant melanoma (mMM).
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Article
Open AccessDose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging
Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries a dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this i...
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Potential Biomarkers for Personalized Radiation Therapy for Patients with Uterine Cervical Cancer
Uterine cervical cancer (UCC) is one of the most prevalent malignant neoplasms in the world. UCC develops beyond the stage in situ and is frequently treated by a combination of intracavitary radiation therapy ...
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Article
Open AccessOutcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall sur...
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Article
Open AccessCorrection to: From IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience
In the original publication [1] one author name was spelled incorrect.
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Article
Open AccessFrom IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience
Despite screening campaigns, cervical cancers remain among the most prevalent malignancies and carry significant mortality, especially in develo** countries. Most studies report outcomes of patients receivin...
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Article
Open AccessDual “mAb” HER family blockade in head and neck cancer human cell lines combined with photon therapy
Head and neck cancer stem cells (CSCs) are highly resistant to treatment. When EGFR is overexpressed in head and neck squamous cell carcinoma (HNSCC), HER2 and HER3 are also expressed. The aim of the present s...
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Article
Open AccessRadiotherapy among nonagenarians with anal or rectal carcinoma: should we avoid or adapt treatment?
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Article
Open AccessRadiotherapy for gynecologic cancer in nonagenarian patients: a framework for new paradigms
No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian patients. We retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gy...
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Article
Hypofractionated radiation therapy for treatment of bladder carcinoma in patients aged 90 years and more: A new paradigm to be explored?
There are only scarce data on the optimal management of patients who present with a bladder carcinoma and who are aged 90 years and older.
