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  1. No Access

    Article

    Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands

    Identification and quantification of low-frequency mutations remain challenging despite improvements in the baseline error rate of next-generation sequencing technologies. Here, we describe a method, termed Sa...

    Joshua D. Cohen, Christopher Douville, Jonathan C. Dudley… in Nature Biotechnology (2021)

  2. No Access

    Article

    Sensitive digital quantification of DNA methylation in clinical samples

    Gene-specific changes in DNA methylation are promising biomarkers, but sensitive quantitative detection of these epigenetic marks remains challenging. Li et al. adapt the so-called BEAMing technology to enable hi...

    Meng Li, Wei-dong Chen, Nickolas Papadopoulos, Steven N Goodman… in Nature Biotechnology (2009)

  3. No Access

    Article

    The role of companion diagnostics in the development and use of mutation-targeted cancer therapies

    Among all the known differences between cancer and normal cells, it is only the genetic differences that unequivocally distinguish the former from the latter. It is therefore not surprising that recent therape...

    Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein in Nature Biotechnology (2006)