40 Result(s)
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Nickolas Papadopoulos
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Cancer therapy with antibodies
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage to normal cells. Targeted therapy has been developed to meet that challenge, showing a substantially increased therapeu...
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TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers
Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1–9. Adults with T cell leukaemias and lymphomas, collect...
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Open AccessReal-time evaluation and adaptation to facilitate rapid recruitment in a large, prospective cohort study
Recruiting large cohorts efficiently can speed the translation of findings into care across a range of scientific disciplines and medical specialties. Recruitment can be hampered by factors such as financial b...
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Open AccessHydrophobic interactions dominate the recognition of a KRAS G12V neoantigen
Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation associated neoantigens (MANAs) are products of genetic alterations, making them highly specific therapeutic targets....
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Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
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Open AccessThe rapid and highly parallel identification of antibodies with defined biological activities by SLISY
The therapeutic applications of antibodies are manifold and the emergence of SARS-CoV-2 provides a cogent example of the value of rapidly identifying biologically active antibodies. We describe an approach cal...
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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, iden...
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Correction to: Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology
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Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands
Identification and quantification of low-frequency mutations remain challenging despite improvements in the baseline error rate of next-generation sequencing technologies. Here, we describe a method, termed Sa...
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Open AccessStructural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic agents, generating remarkable responses in the clinic for a subset of human cancers. One major challenge precluding the ...
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Open AccessLandscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows sever...
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Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology
Urine cytology is an essential element of the diagnostic work up of hematuria. A significant proportion of cases continue to be placed in the “atypical” or “suspicious” categories of the Paris system for urine...
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Pathophysiology of ctDNA Release into the Circulation and Its Characteristics: What Is Important for Clinical Applications
The clinical implications of being able to accurately detect tumor-derived DNA in the circulation, termed circulating tumor DNA (ctDNA), could be enormous. Already, a plethora of clinical applications is under...
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Open AccessCorrection to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
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Open AccessPersistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (...
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Open AccessGenomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma
Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for ONB, here we perform whole exome and whole genome seq...
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Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome
Cytokine release syndrome (CRS) is a life-threatening complication of several new immunotherapies used to treat cancers and autoimmune diseases1–5. Here we report that atrial natriuretic peptide can protect mice ...
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Precancerous neoplastic cells can move through the pancreatic ductal system
Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. However, the evolutionary and genetic relationships among co-existing lesions are unclear....
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Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder
Our group and others have previously demonstrated the presence of TERT promoter mutations (TERT-mut) in 60–80% of urothelial carcinomas and some of their histologic variants. Five other genes have been frequently...
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Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer
Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient ...
