5 Result(s)

Article

Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles

Development of a malaria vaccine that blocks transmission of different parasite stages to humans and mosquitoes is considered critical for elimination efforts. A vaccine using Pfs25, a protein on the surface o...

Nicholas J. MacDonald, Kavita Singh, Karine Reiter, Vu Nguyen… in npj Vaccines (2023)

Article

Author Correction: A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Camila H. Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D. Galson… in Nature Communications (2022)

Article

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gam...

Camila H. Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D. Galson… in Nature Communications (2021)

Article

Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 com...

Kavita Singh, Martin Burkhardt, Sofia Nakuchima, Raul Herrera… in Communications Biology (2020)

Article

Limited polymorphism in Plasmodium falciparum ookinete surface antigen, von Willebrand factor A domain-related protein from clinical isolates

As malaria becomes increasingly drug resistant and more costly to treat, there is increasing urgency to develop effective vaccines. In comparison to other stages of the malaria lifecycle, sexual stage antigens...

Jack S Richards, Nicholas J MacDonald, Damon P Eisen in Malaria Journal (2006)