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  1. Article

    Open Access

    Periostin drives extracellular matrix degradation, stemness, and chemoresistance by activating the MAPK/ERK signaling pathway in triple–negative breast cancer cells

    Adipose tissue, which is mainly composed of adipocytes, is a crucial component of the tumor microenvironment, particularly in breast cancer. Adipocytes surround breast cancer cells and may participate in cell‒...

    **na Wu, Jia Li, Huiya Xu, Ni Qiu, **aojia Huang… in Lipids in Health and Disease (2023)

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  2. Article

    Open Access

    Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

    Resistance to Herceptin represents a significant challenge for successful treatment of HER2-positive breast cancer. Here, we show that in Herceptin-sensitive cells, FOXO3a regulates specific miRNAs to control ...

    Liyun Luo, Zhijie Zhang, Ni Qiu, Li Ling, **aoting Jia, Ying Song… in Nature Communications (2021)

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  3. Article

    Open Access

    FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis

    Metastasis remains the major obstacle to improved survival for breast cancer patients. Downregulation of FOXO3a transcription factor in breast cancer is causally associated with the development of metastasis t...

    Ying Song, Shanshan Zeng, Guopei Zheng, Danyang Chen, Pan Li, Mingqiang Yang… in Oncogene (2021)

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  4. Article

    Open Access

    KLF5 regulated lncRNA RP1 promotes the growth and metastasis of breast cancer via repressing p27kip1 translation

    Increasing evidence suggest that lncRNAs (long noncoding RNAs) play important roles in human cancer. Breast cancer is a heterogeneous disease and the potential involvement of lncRNAs in breast cancer remains u...

    **aoting Jia, Lejuan Shi, **aorong Wang, Liyun Luo, Li Ling… in Cell Death & Disease (2019)

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  5. No Access

    Article

    LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer

    Breast cancer is a heterogeneous disease, and triple-negative breast cancer (TNBC) continues to be a serious health problem. The potential involvement of lncRNAs in TNBC progression remains unexplored. Here, w...

    Liyun Luo, Hailin Tang, Li Ling, Nan Li, **aoting Jia, Zhijie Zhang… in Oncogene (2018)

  6. No Access

    Article

    Influence of Metallic Materials on SF6 Decomposition Components under Positive DC Partial Discharge

    Determination of the influence and mechanism of metallic materials on SF6 decomposition under direct current (DC) partial discharge is one of the key aspects to improve SF6 decomposition component analysis (DCA)....

    Ju Tang, Zhengqin Cao, Fu** Zeng, Qiang Yao… in Plasma Chemistry and Plasma Processing (2017)

  7. Article

    Open Access

    SRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer

    Patients with triple-negative breast cancers (TNBC) are at a high risk for a recurrent or metastatic disease, and the molecular mechanisms associated with this risk are unclear. Proteoglycan serglycin (SRGN) p...

    Z Zhang, Y Deng, G Zheng, X Jia, Y **ong, K Luo, Q Qiu, Ni Qiu, J Yin, M Lu… in Oncogenesis (2017)

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  8. No Access

    Article

    Development of W/O Microemulsion for Transdermal Delivery of Iodide Ions

    The objective of this study was to develop a water-in-oil (w/o) microemulsion which can be utilized as a transdermal delivery for iodide ions. Several w/o microemulsion formulations were prepared utilizing Spa...

    Hao Lou, Ni Qiu, Catherine Crill, Richard Helms, Hassan Almoazen in AAPS PharmSciTech (2013)

  9. Article

    Nitroglycerin enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via nitric oxide pathway

    To investigate the effect of nitroglycerin (NTG) on cell proliferation and osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells (HBMSC) and its mechanisms.

    Li Huang, Ni Qiu, Che Zhang, Hong-yan Wei, Ya-lin Li… in Acta Pharmacologica Sinica (2008)

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