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Article
Open AccessPresence of intratumoral platelets is associated with tumor vessel structure and metastasis
Platelets play a fundamental role in maintaining hemostasis and have been shown to participate in hematogenous dissemination of tumor cells. Abundant platelets were detected in the tumor microenvironment outsi...
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Article
Open AccessDifferential expression of TIM-3 between primary and metastatic sites in renal cell carcinoma
Due to the significant heterogeneity of renal cell carcinoma (RCC), immune checkpoints may express differently between primary and metastatic tumor. We aimed to evaluate the differential expression of TIM-3 be...
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Article
Open AccessDifferential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma
In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. However, immune checkpoints may express differently between primary and metastatic tumor....