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Article
Open AccessPatients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma
TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare but highly heterogeneous renal cell carcinoma (RCC) entity, of which the clinical treatment landscape is largely undefined. This study aims to evaluate a...
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Article
MDT perspective: intraductal carcinoma of the prostate: implication for diagnosis and treatment
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Article
Open AccessBenign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases
Leiomyoma is the most prevalent benign tumor of the female reproductive system. Benign metastasizing leiomyoma (BML) is a rare phenomenon that presents at distant sites, typically the lungs, exhibiting histopa...
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Article
Production of Functional Materials Derived from Regenerated Silk Fibroin by Utilizing 3D Printing and Biomimetic Enzyme-induced Mineralization
Critical-sized bone defects, commonly encountered in clinical orthopedic surgery, present a significant challenge. One of the promising solutions is to prepare synthetic bone substitute materials with precise ...
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Article
Open AccessA novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression
Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB. Aberrant expression of FGFR1 due ...
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Article
Investigation on eXtreme Gradient Boosting for cutting force prediction in milling
Accurate prediction of cutting forces is critical in milling operations, with implications for cost reduction and improved manufacturing efficiency. While traditional mechanistic models provide high accuracy, ...
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Article
Open AccessDiagnostic value of contrast-enhanced ultrasonography in the preoperative evaluation of lymph node metastasis in papillary thyroid carcinoma: a single-center retrospective study
Contrast-enhanced ultrasound (CEUS) has been recently used for the assessment of cervical lymph node metastasis (LNM) to guide surgical operation in patients with papillary thyroid carcinoma (PTC). However, th...
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Article
Neuroendocrine differentiation predicts the therapeutic efficacy of abiraterone and docetaxel as first-line therapy in metastatic castration-resistant prostate cancer
We aim to explore the predictive value of neuroendocrine differentiation (NED) in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving abiraterone or docetaxel as first-line therapy.
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Article
Open AccessPhotomodulation alleviates cellular senescence of aging adipose-derived stem cells
Mesenchymal stem cells (MSCs) therapies are emerging as a promising approach to therapeutic regeneration. Therapeutic persistence and reduced functional stem cells following cell delivery remain critical hurdl...
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Article
Fetal periventricular pseudocysts: is MRI evaluation needed? What is the long-term neurodevelopmental outcome? Systematic review and meta-analysis
To explore the value of magnetic resonance imaging (MRI) in fetuses with periventricular pseudocysts (PVPC) and the neurodevelopmental outcomes of these fetuses via meta-analysis.
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Article
Open AccessGenomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma
Fumarate hydratase–deficient renal cell carcinoma (FH-RCC) is a rare highly aggressive subtype of kidney cancer for which the distinct genomic, transcriptomic, and evolutionary relationships between metastatic...
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Article
On machining K417 superalloy with sliding self-propelled rotary tools: simulation and experimental investigation
Rotary tools are increasingly being used in the cutting of superalloy due to their superior wear resistance and long life, while the sliding self-propelled rotary tools are the most widely used due to their si...
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Article
Neutronics analysis of a subcritical blanket system driven by a gas dynamic trap-based fusion neutron source for 99Mo production
Gamma-emitting radionuclide 99mTc is globally used for the diagnosis of various pathological conditions owing to its ideal single-photon emission computed tomography (SPECT) characteristics. However, the short ha...
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Chapter and Conference Paper
Experimental Technology and Application of Multiple Thermal Recovery Development in Heavy Oil Reservoir
The heavy oil reservoirs in Liaohe Oilfield are characterized by multiple oil-bearing formations, multiple complex structure faults, multiple reservoir types, multiple oil product types and deep oil reservoirs...
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Article
Extraventricular site indicates higher grade but better prognosis in adult supratentorial ependymomas: a 14-year single-center retrospective cohort
Supratentorial extraventricular ependymoma (STEE) and supratentorial intraventricular ependymoma (STIE) are two subsets of supratentorial ependymoma (SE). These two subsets have similar gene features and only ...
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Article
Discrepancies in Simulated Ocean Net Surface Heat Fluxes over the North Atlantic
The change in ocean net surface heat flux plays an important role in the climate system. It is closely related to the ocean heat content change and ocean heat transport, particularly over the North Atlantic, w...
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Article
A review on dynamics in micro-milling
This paper is a review of all recent and most relevant research in the field of dynamics in micro-milling processes. It associates the recent research works, future trends, and thoughts in the field of dynamic...
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Article
A primary rectal neoplasm with novel DDX5-TFEB fusion
We report a case of primary rectal neoplasm with a novel DDX5-TFEB fusion in a 14-year-old boy. Histologically, the neoplasm was composed of epithelioid tumor cells with abundant clear to eosinophilic cytoplasm, ...
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Article
Open AccessIntegrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common and highly heterogeneous subtype of renal cell carcinoma. Dysregulated basal cell adhesion molecule (BCAM) gene is associated with poor prognosis in vari...
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Article
Open AccessCDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma
Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it’s role in glioma, which is ranked as one of the common primary malignant ...
