14 Result(s)
within
Nhat Trung Doan
Neurosciences
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Article
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we id...
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Article
Genetic control of variability in subcortical and intracranial volumes
Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a nove...
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Open AccessBrain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation...
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Article
Open AccessUsing structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (M...
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Article
Open AccessTesting relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents
Human brain development involves spatially and temporally heterogeneous changes, detectable across a wide range of magnetic resonance imaging (MRI) measures. Investigating the interplay between multimodal MRI ...
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Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in...
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Article
Open AccessDose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Carriers of large recurrent copy number variants (CNVs) have a higher risk of develo** neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizoph...
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Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using struct...
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Open AccessReproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain ma...
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Article
Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder
The thalamus is a highly connected subcortical structure that relays and integrates sensory and cortical information, which is critical for coherent and accurate perceptual awareness and cognition. Thalamic dy...
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Open AccessHuman subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors i...
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Article
Delayed stabilization and individualization in connectome development are related to psychiatric disorders
This study on neurodevelopment of functional networks reveals a network tuning process that transforms the human connectome into a stable, individualized wiring pattern. Delay in this tuning was associated wit...
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cogni...
