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Open AccessA novel multi-task machine learning classifier for rare disease patterning using cardiac strain imaging data
To provide accurate predictions, current machine learning-based solutions require large, manually labeled training datasets. We implement persistent homology (PH), a topological tool for studying the pattern o...
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Article
The Role of Artificial Intelligence in Echocardiography: A Clinical Update
In echocardiography, there has been robust development of artificial intelligence (AI) tools for image recognition, automated measurements, image segmentation, and patient prognostication that has created a mo...
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Quantitative single photon emission computed tomography derived standardized uptake values on 99mTc-PYP scan in patients with suspected ATTR cardiac amyloidosis
Technetium-99 pyrophosphate scintigraphy (99mTc-PYP) provides qualitative and semiquantitative diagnosis of ATTR cardiac amyloidosis (ATTR-CA) using the Perugini scoring system and heart/contralateral heart ra...
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Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine
Myocardial regeneration is a promising alternative to heart transplantation, but the ideal stem cell type remains unknown due to conflicting results in clinical trials. Trial discrepancies may be addressed by ...
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Open AccessHistopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model
Multi-walled carbon nanotubes and nanofibers (CNT/F) have been previously investigated for their potential toxicities; however, comparative studies of the broad material class are lacking, especially those wit...
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Open AccessA vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients
Patients with influenza and SARS-CoV2/Coronavirus disease 2019 (COVID-19) infections have a different clinical course and outcomes. We developed and validated a supervised machine learning pipeline to distingu...
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Open AccessPhysicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities
Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxici...
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Open AccessGender differences in murine pulmonary responses elicited by cellulose nanocrystals
Cellulose-based materials have been used for centuries to manufacture different goods derived from forestry and agricultural sources. In the growing field of nanocellulose applications, its uniquely engineered...
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Open AccessEarly integration of the individual student in academic activities: a novel classroom concept for graduate education in molecular biophysics and structural biology
A key challenge in interdisciplinary research is choosing the best approach from a large number of techniques derived from different disciplines and their interfaces.
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Open AccessDiscovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen
HIV-1 Nef is a viral accessory protein critical for AIDS progression. Nef lacks intrinsic catalytic activity and binds multiple host cell signaling proteins, including Hck and other Src-family tyrosine kinases...
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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Recognition of injured mitochondria for degradation by macroautophagy is essential for cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner mitochondrial membrane phospholipid....
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Open AccessFactoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos
Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurri...
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A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death
The risk of radionuclide release in terrorist acts or exposure of healthy tissue during radiotherapy demand potent radioprotectants/radiomitigators. Ionizing radiation induces cell death by initiating the sele...
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Open AccessHuman immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles
HIV-1 Vpr, a nonstructural viral protein associated with virus particles, has a positive role in the efficient transport of PIC into the nucleus of non-dividing target cells and enhances virus replication in p...
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Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
We have shown previously that single-walled carbon nanotubes can be catalytically biodegraded over several weeks by the plant-derived enzyme, horseradish peroxidase1. However, whether peroxidase intermediates gen...
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Article
Open AccessPreferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors
Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors that play important roles in synaptic plasticity and other neuro-physiological and pathological processes. Allosteric mGluR ligands are...
