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Article
Open AccessA common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate th...
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Article
Open AccessEpigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has ass...
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Article
Open AccessAn integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell ...
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Article
Open AccessAuthor Correction: Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
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Article
Open AccessNasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Bioban...
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Article
Open AccessType 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expre...
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Article
Open AccessDissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium
Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium and goes on to drive development of most chronic lung diseases. Here, through single cell RNA-sequencing analysis ...
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Article
Open AccessCadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity
Polarization of the airway epithelial cells (AECs) in the airway lumen is critical to the proper function of the mucociliary escalator and maintenance of lung health, but the cellular requirements for polariza...
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Computational Analysis of RNA-Seq Data from Airway Epithelial Cells for Studying Lung Disease
Airway epithelial cells (AECs) play a central role in the pathogenesis of many lung diseases. Consequently, advancements in our understanding of the underlying causes of lung diseases, and the development of n...
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Article
What determines the spatial extent of landscape effects on species?
Landscape ecologists are often interested in measuring the effects of an environmental variable on a biological response; however, the strength and direction of effect depend on the size of the area within whi...
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Article
Habitat amount, not habitat configuration, best predicts population genetic structure in fragmented landscapes
Landscape structure shapes the genetic structure of populations by delimiting spatial patterns of dispersal and reproduction across generations. Thus, descriptions of human-altered landscapes can be used to pr...
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Article
The bioinvasion of Guam: inferring geographic origin, pace, pattern and process of an invasive lizard (Carlia) in the Pacific using multi-locus genomic data
Invasive species often have dramatic negative effects that lead to the deterioration and loss of biodiversity frequently coupled with the burden of expensive biocontrol programs and subversion of socioeconomic...
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Article
Microsatellites isolated from the North American ground skink (Scincella lateralis)
Thirteen polymorphic microsatellite markers were developed in the North American ground skink, Scincella lateralis, for use in landscape and population genetic research. Loci were genotyped for a sample of 37 liz...
