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Article
SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Mu...
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Article
Open AccessThe transcription regulator ATF4 is a mediator of skeletal muscle aging
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging are not well understood. To bette...
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Protocol
Quantification and Identification of Post-Translational Modifications Using Modern Proteomics Approaches
Post-translational modifications (PTMs) occur dynamically, allowing cells to quickly respond to changes in the environment. Lysine residues can be targeted by several modifications including acylations (acetyl...
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Article
Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its associated diseases. However, the mechanism for this decline is unclear. Here, we show that pro-inflammatory M1-like...
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Article
Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure
Inhibition of mammalian target of rapamycin complex I (mTORC1) by rapamycin improves cardiac function in both aging and heart failure. While the protective mechanisms are not fully understood in mammals, they ...
