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  1. No Access

    Article

    High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas

    In contrast to pilocytic astrocytomas (WHO grade I gliomas) that are circumscribed and cured by surgical resection, invasion is a hallmark of grades II–IV gliomas. Proteases play a major role in the invasion p...

    Carole Colin, Brigitte Voutsinos-Porche, Isabelle Nanni… in Acta Neuropathologica (2009)

  2. No Access

    Article

    PTEN methylation and expression in glioblastomas

    The tumor suppressor gene PTEN on chromosome 10q23.3 regulates the Akt signaling pathway and modulates cell growth and apoptosis. The PTEN gene is mutated in 20–40% of glioblastomas. In this study, we assessed wh...

    Nathalie Baeza, Michael Weller, Yasuhiro Yonekawa, Paul Kleihues… in Acta Neuropathologica (2003)

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    Article

    AXIN1 mutations but not deletions in cerebellar medulloblastomas

    Medulloblastoma is a malignant, invasive embryonal tumour of the cerebellum which manifests preferentially in children. A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrom...

    Nathalie Baeza, Jun Masuoka, Paul Kleihues, Hiroko Ohgaki in Oncogene (2003)

  4. No Access

    Article

    Attenuation of FGF signalling in mouse β-cells leads to diabetes

    Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and cell differentiation in many organs, including the develo** pancreas1,2. Here we show that the FGF receptors (FGFRs...

    Alan W. Hart, Nathalie Baeza, Åsa Apelqvist, Helena Edlund in Nature (2000)