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  1. Article

    Open Access

    SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies

    Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant challenges for contemporary biological assays....

    Michael C Ryan, Barry R Zeeberg, Natasha J Caplen, James A Cleland… in BMC Bioinformatics (2008)

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  2. No Access

    Article

    Gene silencing through RNA interference: Potential for therapeutics and functional genomics

    A major focus of biology is determining the role that specific genes play within a cell. The ability to control gene expression is a powerful tool for biologists, and methods that facilitate the expression of ...

    David O. Azorsa, Spyro Mousses, Natasha J. Caplen in Letters in Peptide Science (2003)