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Open AccessProfessionally led support groups for people living with advanced or metastatic cancer: a systematic sco** review of effectiveness and factors critical to implementation success within real-world healthcare and community settings
To examine the effectiveness of professionally led support groups for people with advanced or metastatic cancer, and identify factors critical to implementation success within real-world settings.
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Open AccessUsing a theory informed approach to design, execute, and evaluate implementation strategies to support offering reproductive genetic carrier screening in Australia
Health care professionals play a central role in offering reproductive genetic carrier screening but face challenges when integrating the offer into practice. The aim of this study was to design, execute, and ...
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Article
Adverse Events in Pregnant Patients Treated with Coronavirus Disease 2019 Therapeutics
Pregnant patients are at high risk of maternal and fetal complications from Coronavirus Disease 2019 (COVID-19) infections. The COVID-19 pandemic prompted a surge in the development and repurposing of therapie...
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Open AccessThe Relationship Between Psychological Distress and Physical Activity Is Non-linear and Differs by Domain: a Cross-Sectional Study
There is increasing evidence for the relationship between physical activity (PA), sedentary behaviour and mental health. Limited data exists on sex-specific associations. We aimed to identify associations betw...
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Open AccessAligning intuition and theory: a novel approach to identifying the determinants of behaviours necessary to support implementation of evidence into practice
Disentangling the interplay between experience-based intuition and theory-informed implementation is crucial for identifying the direct contribution theory can make for generating behaviour changes needed for ...
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Open AccessRetrospective analysis of factors influencing the implementation of a program to address unprofessional behaviour and improve culture in Australian hospitals
Unprofessional behaviour among hospital staff is common. Such behaviour negatively impacts on staff wellbeing and patient outcomes. Professional accountability programs collect information about unprofessional...
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Open AccessLynch syndrome testing of colorectal cancer patients in a high-income country with universal healthcare: a retrospective study of current practice and gaps in seven australian hospitals
To inform effective genomic medicine strategies, it is important to examine current approaches and gaps in well-established applications. Lynch syndrome (LS) causes 3–5% of colorectal cancers (CRCs). While gui...
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Open AccessWould they accept it? An interview study to identify barriers and facilitators to user acceptance of a prescribing advice service
Few studies have explored the factors influencing user uptake of interventions designed to enhance therapeutic drug monitoring (TDM). This study aimed to identify barriers and facilitators to acceptance of a p...
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Pilot study of an online training program to increase genetic literacy and communication skills in oncology healthcare professionals discussing BRCA1/2 genetic testing with breast and ovarian cancer patients
The increasing use of genetic testing for BRCA1/2 and other pathogenic variants in the management of women with breast and ovarian cancer necessitates increased genetic literacy in oncology healthcare professiona...
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Stakeholder attitudes towards establishing a national genomics registry of inherited cancer predisposition: a qualitative study
This study aimed to describe the acceptability and perceived barriers and enablers to establish a national registry targeting carriers of pathogenic variants in cancer susceptibility genes from stakeholders’ p...
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Open AccessThe design, implementation, and effectiveness of intervention strategies aimed at improving genetic referral practices: a systematic review of the literature
Despite rapid advancements in genetics and genomics, referral practices remain suboptimal. This systematic review assesses the extent to which approaches from implementation science have been applied to addres...
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Open AccessPsychosocial impact of COVID-19 on cancer patients, survivors, and carers in Australia: a real-time assessment of cancer support services
This study aimed to explore the psychosocial impacts of the coronavirus disease (COVID-19) pandemic on cancer patients, survivors, and carers in Australia.
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Nitrogen, water, and phosphorus uptake as functions of fine-root mass in greenhouse microcosms of Poa pratensis
Understanding resource uptake as a function of fine-root mass is important for both basic ecological theory and applied biogeochemical cycling models. We measured plant population nitrogen uptake rate (PP-NUR)...
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Open AccessAn RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases: a study protocol for the SITA (Should I Take Aspirin?) trial
Australian guidelines recommend that all people aged 50–70 years old actively consider taking daily low-dose aspirin (100–300 mg per day) for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC). Des...
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Open AccessMouse primary microglia respond differently to LPS and poly(I:C) in vitro
Microglia, CNS resident innate immune cells, respond strongly to activation of TLR3 and TLR4, which recognize viral dsRNA poly(I:C) and bacterial endotoxin LPS, respectively. However, few studies have thorough...
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Open AccessInhaled methoxyflurane (Penthrox) for analgesia in trauma: a systematic review protocol
More than 75% of patients presenting to the Emergency Department are suffering symptoms of pain. Despite this, 67% will not receive any analgesia. Methoxyflurane is a fluorinated hydrocarbon gas which has anal...
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Open AccessProceedings of the Virtual 3rd UK Implementation Science Research Conference
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Open AccessAligning intuition and theory: enhancing the replicability of behaviour change interventions in cancer genetics
Despite considerable encouragement for healthcare professionals to use or be clear about the theory used in their improvement programmes, the uptake of these approaches to design interventions or report their ...
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Open AccessThe health and economic impact of implementation strategies for improving detection of hereditary cancer patients—protocol for an in-depth cost-effectiveness evaluation with microsimulation modelling
Patients with Lynch syndrome (an inherited cancer predisposition syndrome) remain largely underdiagnosed despite clinically and cost-effective testing strategies to detect patients. This is largely due to poor...
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Open AccessOptimisation: defining and exploring a concept to enhance the impact of public health initiatives
Repeated, data-driven optimisation processes have been applied in many fields to rapidly transform the performance of products, processes and interventions. While such processes may similarly be employed to en...
