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  1. No Access

    Article

    Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer

    ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix–loop–helix transcription factors. Certain human primary breast cancers reportedly have low or no express...

    Naoyuki Umetani, Takuji Mori, Kazuo Koyanagi, Masaru Shinozaki, Joseph Kim… in Oncogene (2005)

  2. No Access

    Article

    Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma

    APAF-1 gene, located at chromosome locus 12q23, is a key factor in the mitochondrial apoptotic pathway downstream of p53, and is a potential tumor suppressor gene. We hypothesized that APAF-1 gene dysfunction due...

    Naoyuki Umetani, Akihide Fujimoto, Hiroya Takeuchi, Masaru Shinozaki… in Oncogene (2004)