17 Result(s)
within
Naoya Sakamoto
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessGGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis
Post-ERCP pancreatitis (PEP) is an acute pancreatitis caused by endoscopic-retrograde-cholangiopancreatography (ERCP). About 10% of patients develop PEP after ERCP. Here we show that gamma-glutamyltransferase ...
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Open AccessExtracting interpretable features for pathologists using weakly supervised learning to predict p16 expression in oropharyngeal cancer
One drawback of existing artificial intelligence (AI)-based histopathological prediction models is the lack of interpretability. The objective of this study is to extract p16-positive oropharyngeal squamous ce...
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Open AccessPressure dependence of metal–silicate partitioning explains the mantle phosphorus abundance
Previous experiments performed below 20 GPa suggested that the metal/silicate partition coefficient of phosphorus (P), DP, extrapolated to typical high-pressure and -temperature conditions of the Earth’s core for...
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Open AccessSerum IL-1β predicts de novo hepatitis B virus reactivation during direct-acting antiviral therapy for hepatitis C, not during anti-cancer/immunosuppressive therapy
De novo hepatitis B virus (HBV) reactivation occurs during direct-acting antiviral (DAA) treatment in hepatitis C virus (HCV)-infected patients with resolved HBV infection. We evaluated the predictive factors,...
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Open AccessPrediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication
Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed t...
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Open AccessPossible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients...
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Open AccessExperimental evidence for hydrogen incorporation into Earth’s core
Hydrogen is one of the possible alloying elements in the Earth’s core, but its siderophile (iron-loving) nature is debated. Here we experimentally examined the partitioning of hydrogen between molten iron and ...
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Open AccessBaseline elevated serum angiopoietin-2 predicts long-term non-regression of liver fibrosis after direct-acting antiviral therapy for hepatitis C
We previously revealed that Angiopoietin-2 (Ang2) predicts non-regression of liver fibrosis based on liver stiffness measurement (LSM) at 24 weeks after anti-hepatitis C virus (HCV) treatment. In this study, w...
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Open AccessEvidence of metasomatism in the interior of Vesta
Diogenites are a group of meteorites that are derived from the interior of the largest protoplanet Vesta. They provide a unique opportunity to understanding together the internal structure and dynamic evolutio...
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Open AccessTri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) that may lead to liver cirrhosis or hepatocellular carcinoma. Here, we examined the diagnostic utility of...
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Open AccessOrganogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts
Reactive oxygen species (ROS) are very harmful to dermal cells, and it is thus important to develop cosmetics that protect the skin from ROS and other stimuli. Repagermanium is a synthetic water-soluble organo...
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Open AccessGenome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma
We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asy...
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Open AccessYoung asteroidal fluid activity revealed by absolute age from apatite in carbonaceous chondrite
Chondritic meteorites, consisting of the materials that have formed in the early solar system (ESS), have been affected by late thermal events and fluid activity to various degrees. Determining the timing of f...
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Open AccessUnderstanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genoty**-based association analysis
Associations of variants located in the HLA class II region with chronic hepatitis B (CHB) infection have been identified in Asian populations. Here, HLA imputation method was applied to determine HLA alleles usi...
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Open AccessCorrection: Corrigendum: Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression
Amino acid (aa) polymorphisms in the hepatitis C virus (HCV) genotype 1b core protein have been reported to be a potent predictor for poor response to interferon (IFN)-based therapy and a risk factor for hepat...
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Open AccessInvolvement of FKBP6 in hepatitis C virus replication
The chaperone system is known to be exploited by viruses for their replication. In the present study, we identified the cochaperone FKBP6 as a host factor required for hepatitis C virus (HCV) replication. FKBP...
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Open AccessAmino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression
Amino acid (aa) polymorphisms in the hepatitis C virus (HCV) genotype 1b core protein have been reported to be a potent predictor for poor response to interferon (IFN)-based therapy and a risk factor for hepat...
