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Article
The genomic landscape of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low ...
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Article
Randomized assessment of delayed intensification and two methods for parenteral methotrexate delivery in childhood B-ALL: Children’s Oncology Group Studies P9904 and P9905
The delayed intensification (DI) enhanced outcome for patients with acute lymphoblastic leukemia (ALL) treated on BFM 76/79 and CCG 105 after a prednisone-based induction. Childrens Oncology Group protocols P9...
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Article
Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation
In leukemic mice, fasting reduces the development of acute lymphoblastic leukemia, but not acute myeloid leukemia, via upregulation of leptin receptor expression and signaling in the leukemic cells.
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Article
Open AccessInherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children
There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding va...
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Article
Childhood Femoral Head Osteonecrosis
Femoral head osteonecrosis (FHO) is potentially a devastating condition of the hip joint that can affect children and adults. The most serious outcome of this condition is the development of painful progressiv...
