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Author Correction: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
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Open AccessEpigenetic reprogramming shapes the cellular landscape of schwannoma
Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the p...
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Article
Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
Understanding of the factors governing immune responses in cancer remains incomplete, limiting patient benefit. In this study, we used mass cytometry to define the systemic immune landscape in response to tumo...
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Article
Break-induced telomere synthesis underlies alternative telomere maintenance
Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in a...
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Article
Familiar ends with alternative endings
The faithful propagation of species requires a complex balance of DNA-repair pathways to maintain genome integrity. New work sheds light on one such poorly understood pathway and its role in certain cancers. See ...
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Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PCC/PGL) are the solid tumour type most commonly associated with an inherited susceptibility syndrome. However, very little is known about the somatic genetic changes lead...
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Article
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
Competitive binding of 53BP1 and BRCA1 determines DNA repair pathway choice at double-strand breaks. New work shows that acetylation of H4K16 by TIP60 tips the balance in favor of BRCA1 by limiting 53BP1 bindi...
