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  1. No Access

    Article

    Development, Quality by Design-Based Optimization, and Stability Assessment of Oral Liquid Formulations Containing Baclofen for Hospital Use

    The absence of oral liquid pharmaceutical forms appropriate for use in pediatric and adult patients with difficulty swallowing is a public health problem, especially in the hospital context. Baclofen is a mus...

    Elisa de Saldanha Simon, Nathalie Ribeiro Wingert, Caren Gobetti… in AAPS PharmSciTech (2022)

  2. No Access

    Article

    Analytical Quality by Design Approach for a Stability-Indicating Method to Determine Apixaban and Its Related Impurities

    Quality by Design (QbD) is a systematic approach that takes predefined objectives and emphasizes process understanding and control. Analytical QbD (AQbD) is widely used when it comes to the development and opt...

    Jéssica B. Ellwanger, Nathalie Ribeiro Wingert, Nadia Maria Volpato… in Chromatographia (2020)

  3. Article

    Open Access

    In vitro toxic evaluation of two gliptins and their main impurities of synthesis

    The presence of impurities in some drugs may compromise the safety and efficacy of the patient’s treatment. Therefore, establishing of the biological safety of the impurities is essential. Diabetic patients ar...

    Camila F. A. Giordani, Sarah Campanharo… in BMC Pharmacology and Toxicology (2019)

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  4. No Access

    Article

    Delapril and manidipine characterization and purity evaluation in raw materials

    This study characterizes the solid-state of delapril hydrochloride (DEL) and manidipine dihydrochloride (MAN) raw materials using different analytical techniques. DEL (D1 and D2) and MAN (M1 and M2) were obtai...

    Vítor Todeschini, Paulo Renato de Oliveira… in Journal of Thermal Analysis and Calorimetry (2014)

  5. No Access

    Article

    Development and Validation of a Discriminative Dissolution Test for Nimesulide Suspensions

    The dissolution test for oral dosage forms has recently widened to a variety of special dosage forms such as suspensions. For class II drugs, such as nimesulide (NMS), this study is very important because form...

    Laís Bastos da Fonseca, Márcio Labastie, Valéria Pereira de Sousa… in AAPS PharmSciTech (2009)

  6. Article

    Open Access

    Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use

    Preterm infants need high amounts of calcium and phosphorus for bone mineralization, which is difficult to obtain with parenteral feeding due to the low solubility of these salts. The objective of this study w...

    Daniela de Oliveira Ribeiro, Bianca Waruar Lobo, Nádia Maria Volpato… in Nutrition Journal (2009)

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  7. No Access

    Article

    Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis

    Purpose. The aim of the work was to study iontophoretic transdermal administration of salmon calcitonin (sCt) in rabbits, with particular attention to drug reservoir composition. A dry sCt disc, to be dissolved ...

    Patrizia Santi, Paolo Colombo, Ruggero Bettini… in Pharmaceutical Research (1997)

  8. No Access

    Article

    Iontophoresis Enhances the Transport of Acyclovir Through Nude Mouse Skin by Electrorepulsion and Electroosmosis

    Purpose. Iontophoresis was employed for enhancing the transdermal delivery of acyclovir through nude mouse skin in vitro, with the aim of understanding the mechanisms responsible for drug transport, in order to ...

    Nadia Maria Volpato, Patrizia Santi, Paolo Colombo in Pharmaceutical Research (1995)