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Article
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
Dose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in nonmalignant tissues. This obstacle can be minimized by targeting c...
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Article
Open AccessFocal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)
Understanding the intricate signaling network involved in triple-negative breast cancer (TNBC) represents a challenge for develo** novel therapeutic approaches. Here, we aim to provide novel mechanistic insi...
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Article
Open AccessEGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ ac...
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Article
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis
Prostate cancer (PCa) innervation contributes to the progression of PCa. However, the precise impact of innervation on PCa cells is still poorly understood. By focusing on muscarinic receptors, which are activ...
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Article
Open AccessLiver stage malaria infection is controlled by host regulators of lipid peroxidation
The facets of host control during Plasmodium liver infection remain largely unknown. We find that the SLC7a11-GPX4 pathway, which has been associated with the production of reactive oxygen species, lipid peroxida...
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Article
Open AccessIdentifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles
Plasmodium parasites have extensive needs from their host hepatocytes during the obligate liver stage of infection, yet there remains sparse knowledge of specific host regulators. Here we...
