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Article
Open AccessNeutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine
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Article
Computational study reveals substituted benzimidazole derivatives’ binding selectivity to PI3Kδ and PI3Kγ
Phosphatidylinositol 3-kinase (PI3K) is a key regulatory kinase in the PI3K/AKT/mTOR signaling pathway, which is involved in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis. ...
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Article
Open AccessRapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant
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Article
Open AccessLipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
Monoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of develo** effective antibodies a...
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Article
Open AccessGlobal correlation and local information flows in controllable non-Markovian open quantum dynamics
In a fully-controllable experiment platform for studying non-Markovian open quantum dynamics, we show that the non-Markovianity could be investigated from the global and local aspects. By mixing random unitary...
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Article
Open AccessGm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation
Many integral membrane proteins might act as indispensable coordinators in specific functional microdomains to maintain the normal operation of known receptors, such as Notch. Gm364 is a multi-pass transmembra...
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Chapter and Conference Paper
THSLRR: A Low-Rank Subspace Clustering Method Based on Tired Random Walk Similarity and Hypergraph Regularization Constraints
Single-cell RNA sequencing (scRNA-seq) technology furnishes us with a certainly forceful tool for exploring biological mechanisms from the perspective of single-cell. By clustering scRNA-seq data, different ty...
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Article
Open AccessLong-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates
Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency u...
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Article
Open AccessPrognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis
Tertiary lymphoid structures (TLSs), organizationally resemble lymph nodes, are frequently present in breast cancer (BCa). It is usually, but not always, associated with a positive prognosis or immunotherapy r...
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Article
Open AccessRational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection
Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic an...
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Article
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids
The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global public health crisis since 2015. ZIKV preferentially infects and targets human neural progenitor cells (hNPCs) and causes ...
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Article
Open AccessIntranasal infection and contact transmission of Zika virus in guinea pigs
Zika virus (ZIKV) is primarily transmitted to humans through mosquito bites or sexual contact. The excretion and persistence of contagious ZIKV in various body fluids have been well documented in ZIKV patients...
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Article
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive ...
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Article
Open AccessA peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently ...
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Article
Open AccessIsolation, identification and genomic characterization of the Asian lineage Zika virus imported to China
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Article
Open AccessAccumulation Mechanisms of CD4+CD25+FOXP3+ Regulatory T Cells in EBV-associated Gastric Carcinoma
Approximately 10% of gastric carcinomas are associated with Epstein-Barr virus (EBV) and are defined as EBV-associated gastric carcinomas (EBVaGCs). EBVaGCs are known to be accompanied by massive CD8+ cytotoxic T...
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Article
Is gastric lymphoepithelioma-like carcinoma a special subtype of EBV-associated gastric carcinoma? New insight based on clinicopathological features and EBV genome polymorphisms
Gastric lymphoepithelioma-like carcinoma (LELC) is a rare entity that is closely associated with Epstein–Barr virus (EBV). However, the EBV latency pattern and genome polymorphisms in gastric LELC have not bee...
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Article
Aberrant gene promoter methylation of p16, FHIT, CRBP1, WWOX, and DLC-1 in Epstein–Barr virus-associated gastric carcinomas
Alterations in global DNA methylation and specific regulatory gene methylation are frequently found in cancer, but the significance of these epigenetic changes in EBV-associated gastric carcinoma (EBVaGC) rema...
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Article
Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosis
To investigate the effects of the potassium-sparing diuretic amiloride on endothelial cell apoptosis during lipopolysaccharide (LPS)-accelerated atherosclerosis.
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Article
Expression, purification and characterization of anti-BAFF antibody secreted from the yeast Pichia pastoris
B-Cell activating factor (BAFF) is critical for B cell survival and maturation; excessive expression of it corrupts B-cell tolerance and may lead to autoimmunity. The gene, scFv-Fc, coding for the antibody of ...
