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Open AccessJNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1
BH3 interacting-domain death agonist (Bid) is a BH3-only pro-apoptotic member of the Bcl-2 family of proteins. Its function in apoptosis is associated with the proteolytic cleavage to the truncated form tBid, ...
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Article
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A
Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin to...
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Article
Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway
FDH (10-formyltetrahydrofolate dehydrogenase) is strongly downregulated in tumors while its elevation suppresses proliferation of cancer cells and induces p53-dependent apoptosis. We have previously shown that...
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Article
Determination of the variance of the endurance limits of machine components by an accelerated method
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Effect of the relative thickness of the flange on the fatigue strength of a shaft in a flange joint
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Evaluating the physicomechanical situation at the tip of a corrosion-mechanical crack
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Fatigue resistance of spindles and shafts in joints with guaranteed interference
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Determining fracture toughness of materials by reference to their mechanical properties