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  1. No Access

    Article

    Permanent acceptance of mouse cardiac allografts with CD40 siRNA to induce regulatory myeloid cells by use of a novel polysaccharide siRNA delivery system

    The CD40/CD154 co-stimulatory pathway is crucial in alloimmune response. We developed a novel small interfering RNA (siRNA) delivery system with a poly-dA extension at the 5′-end of the siRNA sense strand that...

    Q Zhang, N Ichimaru, S Higuchi, S Cai, J Hou, M Fu**o, N Nonomura… in Gene Therapy (2015)

  2. No Access

    Article

    Electroporation-mediated HGF gene transfection protected the kidney against graft injury

    The annual rate of kidney graft loss caused by chronic allograft nephropathy (CAN) has not improved over the past decade. Recent reports suggest that acute renal ischemia results in development of CAN. The goa...

    Y Isaka, K Yamada, Y Takabatake, M Mizui, M Miura-Tsujie, N Ichimaru… in Gene Therapy (2005)

  3. No Access

    Article

    Clinocopathological evaluation in non-episode biopsies of renal transplant allograft

    Histopathological findings in renal allograft with stable function remain unclear. We therefore performed non-episode biopsy in the long-surviving renal allograft to investigate the histopathological changes....

    K. Toki, M. Kyo, S. Takahara, M. Hatori, K. Morozumi… in Transplant International (2000)

  4. No Access

    Article

    Low-dose tacrolimus (FK506)-based immunosuppressive protocol in living donor renal transplantation

    In order to avoid the side effects of tacrolimus (FK506), a low-dose FK506-based regimen was started from 1 June 1991. The dose was adjusted to maintain the FK506 whole blood trough level at 15–20 ng/ml for 7...

    Y. Kokado, S. Takahara, M. Kyo, N. Ichimaru, W. **g-Ding… in Transplant International (1998)