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  1. No Access

    Article

    Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

    Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chl...

    N. A. Grigorenko, M. A. Khomutov, A. R. Simonian… in Russian Journal of Bioorganic Chemistry (2016)

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    Article

    Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism

    Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine metabolism and the functions of spermine and spermid...

    A. R. Khomutov, T. A. Keinanen, N. A. Grigorenko, M. T. Hyvonen… in Molecular Biology (2009)

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    New Charge-Deficient Agmatine Analogues

    N,N′-Di-Boc-N″-triflylguanidine was demonstrated to be an efficient guanidinylation reagent for O-substituted hydroxylamines. N-(3-Aminooxypropyl)- and N-(3-aminopropoxy)guanidines, previously unknown isosteric ...

    A. R. Simonyan, N. A. Grigorenko, J. Vepsalainen… in Russian Journal of Bioorganic Chemistry (2005)

  4. No Access

    Article

    A Charge-Deficient Analogue of Spermine with Chelating Properties

    1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu2+ ions. Possible applications of this...

    A. R. Khomutov, N. A. Grigorenko, S. G. Skuridin… in Russian Journal of Bioorganic Chemistry (2005)

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    Article

    New syntheses of α-methyl- and α,α′-dimethylspermine

    α-Methylspermine and α,α′-dimethylspermine were synthesized in high overall yields starting from N-(benzyloxycarbonyl)-3-aminobutanol in order to study polyamine biochemistry in vitro and in vivo.

    N. A. Grigorenko, J. Vepsalainen, A. Jarvinen… in Russian Journal of Bioorganic Chemistry (2005)

  6. No Access

    Article

    A New Synthesis of α-Methylspermidine

    A five-step synthesis of α-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermi...

    N. A. Grigorenko, J. Vepsalainen, A. Jarvinen… in Russian Journal of Bioorganic Chemistry (2004)