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Article
Characterization of peripheral blood T-cell subpopulation of bladder cancer patients
The levels of immune reactivity of peripheral and blood T-lymphocytes were evaluated in 37 bladder cancer patients and 31 age-matched controls. T-lymphocyte subsets were quantified by monoclonal antibodies, an...
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Article
Effects of a thymic hormone, THF, on tumor-bearing mice and tumor-resected mice
The administration of THF (thymus humoral factor) to mice bearing a chemically induced fibrosarcoma was followed by a significant improvement of the in vivo anti-tumor reactivity, as measured in the Winn assay...
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Article
Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice
The effect of lymphocytes from normal mice on the growth of a syngeneic, radiation-induced, T-cell-derived lymphoma was investigated. Thymus and spleen cells enhanced the growth of admixed lymphoma cells in a ...
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Article
39 THE EFFECT OF THE IN IMMUNOSUPPRESSED CHILDREN WITH LYMPHO PROLIFERATIVE DISEASES
THF, a partially purified Thymic Hormone, was shown to restore the impaired cell mediated immunity (CMI) and reduce the visceral complications in 4 children with acute leukemia and generalized varicella. Twelv...
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Article
Effect of Thymic Humoral Factor on Cellular Immune Functions of Normal Children and of Pediatric Patients with Ataxia Telangiectasia and Down's Syndrome
Summary: Cellular immune functions of nine Down's syndrome patients and of nine with Ataxia telangiectasia vs. nine normal children and nine cord bloods, were evaluated using in vitro assays of peripheral blood l...
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Chapter
Effect of Thymic Humoral Factor (THF) In Vitro on Bone Marrow and Blood Cells from B, T and Null Cell Acute Lymphatic Leukemia (ALL)
The nature of null cell ALL is a matter of controversy. The findings of Topuz et al. (1) indicate a T cell lineage of the null cells whereas the studies of Fu et al. (2) and of Kaplan et al. (3) provide eviden...
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Article
THE POTENTIAL OF THYMUS HUMORAL FACTOR (THE) TREATMENT OF IMMUNODEFICIENT PATIENTS
Therapeutic trials with THF in cellular immunodeficient patients were attempted. Peripheral blood lymphocytes (PBL) were separated on Picoll isopaque gradients and tests of in vitro T-cell functions were perfo...
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Chapter
Isolation and Partial Chemical Characterization of THF, A Thymus Hormone Involved in Immune Maturation of Lymphoid Cells
Humoral factors of the thymus participate in the processes which lead to maturation and acquisition of immunocompetence of cells of the lymphoid system (1,2). We have demonstrated that THF, a thymic factor par...
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Article
Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro a...
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Chapter
Thymus Extracts Induce Differentiation of Thymus Derived Cells
Interaction of thymus and bone marrow derived cells in response to a variety of antigens has been well documented (1–4). However, little is known about the development and differentiation of these cell populat...
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Article
A Possible Two-Stage Mechanism in Rhabdomyosarcoma Induction in Rats
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Article
An Experimental Analysis of the “Hair Cycle Effect” in Mouse Skin Carcinogenesis