21 Result(s)

Article

Qualifications and training of adult stem cell donor recruiters: recommendations by the World Marrow Donor Association

A H Schmidt, B Amer, M Halet, S Hildebrand, N Sacchi in Bone Marrow Transplantation (2013)

Article

Chronic GVHD is associated with inferior relapse risk irrespective of stem cell source among patients receiving transplantation from unrelated donors

Chronic GVHD (cGVHD) has been associated with reduced risk of relapse after allo-SCT for onco-hematological disease due to a graft-vs-malignancy effect. Here we retrospectively analyzed a series of 802 adult p...

A Signori, R Crocchiolo, R Oneto, N Sacchi, M P Sormani… in Bone Marrow Transplantation (2012)

Article

The conundrum of HLA-DRB1*14:01/*14:54 and HLA-DRB3*02:01/*02:02 mismatches in unrelated hematopoietic SCT

Uncertainty still exists on the role of polymorphisms outside the HLA-DRB1 binding site or inside the HLA-DRB3 binding groove in unrelated hematopoietic SCT (HSCT). The ideal model to solve the conundrum consi...

A Pasi, R Crocchiolo, M Bontempelli, C Carcassi, G Carella… in Bone Marrow Transplantation (2011)

Article

Standards, regulations and accreditation for registries involved in the worldwide exchange of hematopoietic stem cell donors and products

The World Marrow Donor Association (WMDA) is working closely with other international organizations working in cellular therapy such as the Worldwide Network for Blood and Marrow Transplantation (WBMT) to deve...

C K Hurley, L Foeken, M Horowitz, B Lindberg, M McGregor… in Bone Marrow Transplantation (2010)

Article

Pre-emptive treatment of acute GVHD: a randomized multicenter trial of rabbit anti-thymocyte globulin, given on day+7 after alternative donor transplants

We have previously shown that hemopoietic stem cell transplant (HSCT) recipients can be stratified on day+7 as having low, intermediate or a high risk of transplant-related mortality (TRM). With the aim of red...

A Bacigalupo, T Lamparelli, G Milone, M P Sormani, F Ciceri… in Bone Marrow Transplantation (2010)

Article

HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry

The importance of HLA donor–recipient matching in unrelated haematopoietic SCT (HSCT) is the subject of debate. In this retrospective study, we analyzed 805 adult patients from the Italian Registry receiving H...

R Crocchiolo, F Ciceri, K Fleischhauer, R Oneto, B Bruno… in Bone Marrow Transplantation (2009)

Article

Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health

The ability to identify unrelated haematopoietic stem cell donors in one country for recipients in another country requires cooperation and standardization in many areas. The donor assessment and testing are v...

N Sacchi, P Costeas, L Hartwell, C K Hurley, C Raffoux… in Bone Marrow Transplantation (2008)

Article

Strategies of the donor search for children with second CR ALL lacking a matched sibling donor

During the last 10 years, the number of alternative Haematopoietic stem cell transplantations (HSCTs) performed on children in Europe has increased significantly and has reached 61% of the allografts. In this ...

E Lanino, N Sacchi, C Peters, S Giardino, V Rocha, G Dini in Bone Marrow Transplantation (2008)

Article

Giuseppe Bigi (1944–2002)

N Sacchi in Leukemia (2007)

Article

Allogeneic hemopoietic stem cell transplants for patients with relapsed acute leukemia: long-term outcome

We assessed the long-term outcome of patients with relapsed acute myeloid (n=86) or acute lymphoid leukemia (n=66), undergoing an allogeneic hemopoietic stem cell transplantation in our unit. The median blast cou...

A Bacigalupo, T Lamparelli, F Gualandi, D Occhini… in Bone Marrow Transplantation (2007)

Article

Progenitor cells trapped in marrow filters can reduce GvHD and transplant mortality

A bone marrow harvest is filtered either in the operating room, in the laboratory or during infusion to the patient. Filters are usually discarded. Little is known of haemopoietic progenitor cells (HPCs) trapp...

D Vicente, M Podestà, A Pitto, S Pozzi, S Lucchetti… in Bone Marrow Transplantation (2006)

Article

Impact of marrow unrelated donor search duration on outcome of children with acute lymphoblastic leukemia in second remission

We analyzed the outcome of 167 consecutive children with second CR acute lymphoblastic leukemia (ALL), for whom an unrelated donor (UD) search was activated between 1989 and 1998 at a median time of 2 months a...

G Dini, M Grazia Valsecchi, C Micalizzi, A Busca, A Balduzzi… in Bone Marrow Transplantation (2003)

Article

Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors

Aims of this study were to verify whether reduction in transplant-related mortality (TRM) of children with acute lymphoblastic leukemia (ALL) in second complete remission (CR) given allogeneic hematopoietic st...

F Locatelli, M Zecca, C Messina, R Rondelli, E Lanino, N Sacchi, C Uderzo… in Leukemia (2002)

Article

Alternative donor transplants for patients with advanced hematologic malignancies, conditioned with thiotepa, cyclophosphamide and antithymocyte globulin

Preparative regimens without total body irradiation (TBI) have been reported for alternative donor hemopoietic stem cell transplants (HSCT). Between 7 September 1994 and 7 June 1999 48 patients with advanced h...

T Lamparelli, MT van Lint, F Gualandi, AM Raiola, M Barbanti… in Bone Marrow Transplantation (2000)

Article

Development of an interphase fluorescent in situ hybridization (FISH) test to detect t(8;21) in AML patients

The translocation (8;21) is a chromosome abnormality associated with acute myeloid leukemia (AML). As a consequence of the translocation the AML1(CBFA2) gene in the 21q22 region is fused to the ETO(CDR,MTG8) gene...

A Hagemeijer, A de Klein, J Wijsman, E van Meerten, GE de Greef, N Sacchi in Leukemia (1998)

Article

Bone marrow transplantation for chronic myeloid leukemia (CML) from unrelated and sibling donors: single center experience

This is a report on 60 consecutive patients with chronic myeloid leukemia (CML) who received an allogeneic bone marrow transplant (BMT) in this Unit. Donors were HLA-identical siblings (SIB) (n = 36) or unrelated...

T Lamparelli, MT Van Lint, F Gualandi, D Occhini, M Barbanti… in Bone Marrow Transplantation (1997)

Article

Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone

Bone marrow from six patients with acute myeloid leukemia (AML) and t(8;21) (q22;q22) or a variant t(8;13;21) was studied by simultaneous analysis of cell morphology and karyotype. Combination of May–Grünwald–...

K van Lom, A Hagemeijer, F Vandekerckhove, GE de Greef, N Sacchi, B Löwenberg in Leukemia (1997)

Chapter and Conference Paper

Significance of Lineage-Associated Transcripts of TdT and ETS1 for Detection of Leukemic Cells

One approach for a rational postremission therapy of acute leukemia is based on detection of residual leukemic blasts. Immunophenoty** with monoclonal antibodies, quantitative DNA analysis for aneuploidy, PC...

C.-M. Wendtner, N. Sacchi, T. Büchner, W. Hiddemann, J. van de Loo… in Acute Leukemias IV (1994)