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Nuclear FOXM1 drives chemoresistance in AML
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Double-balloon enteroscopy in Ireland in the capsule endoscopy era
The availability of double-balloon enteroscopy (DBE) and small bowel capsule endoscopy (SBCE) in Ireland has revolutionised our approach to the diagnosis and treatment of small bowel disorders.
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Allostimulatory activity of CD133+ hematopoietic cells
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Improved outcomes with novel agents and auto-SCT for multiple myeloma in African-American patients
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Open AccessGermline BRCA1 mutations increase prostate cancer risk
Prostate cancer (PrCa) is one of the most common cancers affecting men but its aetiology is poorly understood. Family history of PrCa, particularly at a young age, is a strong risk factor. There have been prev...
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Open AccessBRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
A family history of prostate cancer (PrCa) is a strong risk factor for the disease, indicating that inherited factors are important in this disease. We previously estimated that about 2% of PrCa cases diagnose...
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Open AccessIdentification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate susceptibility gene, KLK3, which ...
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Article
Plerixafor given before the third leukapheresis to rescue an unsuccessful stem cell mobilization with CY and G-CSF
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Reliability of a pretransplant i.v. BU test dose performed 2 weeks before myeloablative FluBu conditioning regimen
A pretransplant test dose of i.v. BU was previously used in pediatric patients undergoing a reduced-intensity allogeneic hematopoietic SCT (HSCT). Here, we used a BU test dose in 23 adult patients who were not...
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Fludarabine/i.v. BU conditioning regimen: myeloablative, reduced intensity or both?
In this study, we utilized a conditioning regimen with fludarabine and myeloablative dose i.v. BU (12.8 mg/kg) (FluBU) in 36 adult patients (median age: 44 years, range: 18–61) with myeloid or lymphoid maligna...
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Comparable kinetics of myeloablation between fludarabine/full-dose busulfan and fludarabine/melphalan conditioning regimens in allogeneic peripheral blood stem cell transplantation
Fludarabine was utilized in the conditioning regimen of 30 adult patients undergoing an allogeneic hematopoietic stem cell transplant. In 18 patients it was combined with full-dose busulfan (FluBu) as a myeloa...
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Prolonged responses after autologous stem cell transplantation in African-American patients with multiple myeloma
Multiple myeloma (MM) has a double incidence in African-American (AA) than in non-AA patients and previous studies have shown a higher mortality in the former patient population. Here, we retrospectively analy...
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The use of blood conservation methods in addition to erythropoietin allows myeloablative allogeneic stem cell transplantation without the use of blood products
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Open AccessDetection of replicative integrity in small colonic biopsies using the BrdUrd comet assay
The alkaline single-cell gel electrophoresis or comet assay is a relatively simple method of measuring DNA single-strand breaks and alkali-labile sites in individual cells. Previously, we have used a combinati...
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Diagnostic and therapeutic ERCP: a large single centre’s experience
Most large published series on endoscopic retrograde cholangiopancreatography (ERCP) are multicentrebased and consequently reflect varying experience.
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Article
Soluble adhesion molecules in inflammatory bowel disease
Soluble adhesion molecules are elevated in a number of inflammatory conditions.
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Systemic levels of free 5-aminosalicylic acid depend on the nature of the 5-aminosalicyclic acid derivative and not on disease activity or extent in patients with inflammatory bowel disease
Several new derivatives of sulphasalazine that make use of its active moiety, 5-aminosalicylic acid (5-ASA), have been introduced for the treatment of inflammatory bowel disease (IBD). In rats short term intra...
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Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality
In de novo t(8;21) AML which shows terminal neutrophilic differentiation, the BCL-2 expression was found to be significantly lower than that in types of other AML regardless of the phenotypic differentiation stat...
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Irish society of gastroenterology
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Waterford surgical october club and surgical section, royal academy of medicine joint surgical symposium at: Waterford regional hospital