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  1. Article

    Erratum: hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway

    Correction to: Oncogene (2006) 25, 4505–4514; doi:10.1038/sj.onc.1209487; published online 17 April 2006 Errors were inadvertently included in Figure 3a of the article mentioned above. In particular, represent...

    C Massard, Y Zermati, A-L Pauleau, N Larochette, D Métivier, L Sabatier… in Oncogene (2013)

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    Article

    Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death

    Following the screening of a battery of distinct small-interfering RNAs that target various components of the apoptotic machinery, we found that knockdown of the voltage-dependent anion channel 1 (VDAC1) was p...

    N Tajeddine, L Galluzzi, O Kepp, E Hangen, E Morselli, L Senovilla, N Araujo… in Oncogene (2008)

  3. Article

    Unexpected role of the phosphate carrier in mitochondrial fragmentation

    A-L Pauleau, L Galluzzi, S R Scholz, N Larochette, O Kepp… in Cell Death & Differentiation (2008)

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    Structure–function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA

    The viral mitochondrial inhibitor of apoptosis (vMIA) encoded by the human cytomegalovirus exerts cytopathic effects and neutralizes the proapoptotic endogenous Bcl-2 family member Bax by recruiting it to mito...

    A-L Pauleau, N Larochette, F Giordanetto, S R Scholz, D Poncet, N Zamzami… in Oncogene (2007)

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    Article

    GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization

    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Here, we report that the protein accumulates in mitochondri...

    A Tarze, A Deniaud, M Le Bras, E Maillier, D Molle, N Larochette, N Zamzami… in Oncogene (2007)

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    Article

    hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway

    hTERT is the catalytic subunit of the telomerase and is hence required for telomerase maintenance activity and cancer cell immortalization. Here, we show that acute hTERT depletion has no adverse effects on th...

    C Massard, Y Zermati, A-L Pauleau, N Larochette, D Métivier, L Sabatier… in Oncogene (2006)

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    Article

    Mitochondria as therapeutic targets for cancer chemotherapy

    Mitochondria are vital for cellular bioenergetics and play a central role in determining the point-of-no-return of the apoptotic process. As a consequence, mitochondria exert a dual function in carcinogenesis....

    L Galluzzi, N Larochette, N Zamzami, G Kroemer in Oncogene (2006)

  8. Article

    Mitochondrial permeability transition in apoptosis and necrosis

    N Zamzami, N Larochette, G Kroemer in Cell Death & Differentiation (2005)

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    Article

    Palmitate induces apoptosis via a direct effect on mitochondria

    The fatty acid palmitate can induce apoptosis. Here we show that the palmitate-induced dissipation of the mitochondrial transmembrane potential (ΔΨ m ), which precedes nuclear ...

    M. A. de Pablo, S. A. Susin, E. Jacotot, N. Larochette, P. Costantini… in Apoptosis (1999)