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Article
Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma
Events mediating transformation from the pre-malignant monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) are unknown. We analyzed gene expression data sets generated on the Aff...
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Article
Clinical and biological significance of RAS mutations in multiple myeloma
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Article
Genetic aberrations and survival in plasma cell leukemia
Plasma cell leukemia (PCL) is an aggressive and rare hematological malignancy that originates either as primary disease (pPCL) or as a secondary leukemic transformation (sPCL) of multiple myeloma (MM). We repo...
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Article
Clinical significance of TP53 mutation in myeloma
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Article
Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma
The nonrandom recurrent nature of chromosome abnormalities in myeloma suggests a role for them in disease pathogenesis. We performed a careful cytogenetic analysis of patients with abnormal karyotypes (n = 254), ...