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Open AccessExtracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine...
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Article
Open AccessRisk factor analysis of the development of severe radiation pneumonitis in patients with non-small cell lung cancer treated with curative radiotherapy, with focus on underlying pulmonary disease
We aim to identify the multifaceted risk factors that can affect the development of severe radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) treated with curative high-dose radioth...
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Gut microbiota differences induced by Toxoplasma gondii seropositivity in stray cats in South Korea
T. gondii is a highly prevalent parasite worldwide, with cats serving as its final host. However, few studies have investigated the impact of T. gondii infection on cat gut microbiota. Therefore, this study exam...
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Open AccessMonitoring measurable residual disease and chimerism in patients with JAK2 V617F-positive myelofibrosis after allogeneic hematopoietic cell transplantation
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Open AccessMetabarcoding of bacteria and parasites in the gut of Apodemus agrarius
The striped field mouse Apodemus agrarius is a wild rodent commonly found in fields in Korea. It is a known carrier of various pathogens. Amplicon-based next-generation sequencing (NGS) targeting the 16S ribosoma...
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Open AccessClinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia
Magnetic resonance-guided radiotherapy (MRgRT) utilization is rapidly expanding, driven by advanced capabilities including better soft tissue imaging, continuous intrafraction target visualization, automatic t...
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Test-retest reliability and validity of the Sitting Balance Measure-Korean in individuals with incomplete spinal cord injury
Cross-cultural reliability and validity.
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Open AccessObesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background
CD44 is a candidate gene for obesity and diabetes development and may be a critical mediator of a systemic inflammation associated with obesity and diabetes.
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Open AccessCorrection to: Analytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2
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Open AccessAnalytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2
Since the initial coronavirus disease outbreak in late 2019 (COVID-19), reverse-transcription real-time polymerase chain reaction (RT-qPCR) has become the gold standard test to detect severe acute respiratory ...
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Open AccessDynamic changes in blood immune cell composition and function in Holstein and Jersey steers in response to heat stress
Heat stress has detrimental effects on livestock via diverse immune and physiological changes; heat-stressed animals are rendered susceptible to diverse diseases. However, there is relatively little informatio...
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Open AccessPrognostic value of measurable residual disease monitoring by next-generation sequencing before and after allogeneic hematopoietic cell transplantation in acute myeloid leukemia
Given limited studies on next-generation sequencing-based measurable residual disease (NGS-MRD) in acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), we...
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Open AccessOptimizing the Diagnostic Strategy to Identify Genetic Abnormalities in Miscarriage
The single most common cause of miscarriage is genetic abnormality.
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Analytical and Potential Clinical Performance of Oncomine Myeloid Research Assay for Myeloid Neoplasms
Next-generation sequencing (NGS) panels have recently been introduced to efficiently detect genetic variations in hematologic malignancies.
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Head-mounted interface for intuitive vision control and continuous surgical operation in a surgical robot system
Although robot-assisted surgeries offer various advantages, the discontinuous surgical operation flow resulting from switching the control between the patient-side manipulators and the endoscopic robot arm can...
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Open AccessCDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia
We identified principal genetic alterations in 97.1% (99/102) of patients with T-acute lymphoblastic leukemia (T-ALL) using integrative genetic analyses, including massive parallel sequencing and multiplex lig...
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Open AccessDevelopment of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering
Pluripotent stem cell transplantation is a promising regenerative strategy for treating intractable diseases. However, securing human leukocyte antigen (HLA)-matched donor stem cells is extremely difficult. Th...
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Cytokine and molecular networks in sepsis cases: a network biology approach
Sepsis is a life-threatening condition of organ dysfunction caused by a dysregulated host immune response to infection. We performed network analysis of cytokine molecules and compared network structures betwe...
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Open AccessRelationship between normal tension glaucoma and Flammer syndrome
Besides intraocular pressure, vascular factors play a role in the pathogenesis of glaucomatous optic neuropathy. One of these potential vascular factors is Flammer syndrome. The purpose of the present study wa...
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Open AccessIdentification of large genomic rearrangement of BRCA1/2 in high risk patients in Korea
While the majority of germline inactivating mutations in BRCA1/2 are small-scale mutations, large genomic rearrangements (LGRs) are also detected in a variable proportion of patients. However, routine genetic met...